ArticleNature communications2015
GABA signalling modulates plant growth by directly regulating the activity of plant-specific anion transporters.
Article in Nature communications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 169 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
169 citing papers in PubMed, 399 citations in OpenAlex.
- Foliar GR24 and γ-aminobutyric acid modulate redox signaling, root-system architecture, and mineral homeostasis in tellurite-stressed wheat (Plant signaling & behavior · 2026Article
- γ-aminobutyric acid is associated with calcium, reactive oxygen species, and nitric oxide responses and enhanced cadmium tolerance inPlant signaling & behavior · 2026Article
- Exogenous γ-aminobutyric acid application delays onset of ripening in Grenache, Chardonnay, and Shiraz grape berries.Plant & cell physiology · 2026Article
- TaGAD2 is a potential downstream effector of Rht5 in controlling wheat plant height.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- Transcriptome analysis reveals the enhancing effects of gamma-aminobutyric acid on the tolerance of grapevines to cadmium stress by reducing cadmium accumulation.Plant biology (Stuttgart, Germany) · 2026Article
- Genome-Wide Identification of the WheatPlants (Basel, Switzerland) · 2026Article
- γ-Aminobutyric Acid (GABA) enhances heat tolerance in rice via integrated antioxidant defense, metabolic homeostasis and heat shock response.BMC plant biology · 2026Article
- GABA Mediates the Enhancement of Maize (Microorganisms · 2026Article
- Advances in the Application of Amino Acids in the Preservation of Postharvest Fruits and Vegetables.Foods (Basel, Switzerland) · 2026Review
- Phytohormone-Mediated Regulation of Plant Cold Stress Tolerance: Signaling, Hormonal Crosstalk, and Translational Perspectives.International journal of molecular sciences · 2026Review
- LED Light Intensity Regulates Nitrogen Assimilation Enzyme Activity and Metabolic Responses in Iceberg and Leaf Lettuce (Plants (Basel, Switzerland) · 2026Article
- SlSLAH2 mediates malate exudation and contributes to aluminum tolerance.Nature communications · 2026Article
- Interpretable multi-omics machine learning reveals drought-driven shifts in plant-microbe interactions.Environmental microbiome · 2026Article
- Decoding the multifunctional role of γ-aminobutyric acid in plant adaptation to drought stress.Planta · 2026Review
- Phosphate Resupply Differentially Impacts the Shoot and Root Proteomes of Arabidopsis thaliana Seedlings.Plant, cell & environment · 2026Article
- Exogenous γ-aminobutyric acid mitigates physiological and transcriptomic responses ofFrontiers in plant science · 2026Article
- Combined transcriptome and metabolome analysis reveals nitrogen-responsive genes and metabolites in sugar beet (Frontiers in plant science · 2026Article
- Article
- Expression Profiling of the Aluminum-Activated Malate Transporter (ALMT) Gene Family in Pumpkin in Response to Aluminum Stress and Exogenous Polyamines.Plants (Basel, Switzerland) · 2025Article
- Metabolic Profiling of Wheat Seedlings Under Oxygen Deficiency and Subsequent Reaeration Conditions.International journal of molecular sciences · 2025Article
109 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issuedCorrigendum: GABA signalling modulates plant growth by directly regulating the activity of plant-specific anion transporters.2015 · Gillham, Matthew [Corrected to Gilliham, Matthew]
Authors and funding
13 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The non-protein amino acid, gamma-aminobutyric acid (GABA) rapidly accumulates in plant tissues in response to biotic and abiotic stress, and regulates plant growth. Until now it was not known whether GABA exerts its effects in plants through the regulation of carbon metabolism or via an unidentified signalling pathway. Here, we demonstrate that anion flux through plant aluminium-activated malate transporter (ALMT) proteins is activated by anions and negatively regulated by GABA. Site-directed mutagenesis of selected amino acids within ALMT proteins abolishes GABA efficacy but does not alter other transport properties. GABA modulation of ALMT activity results in altered root growth and altered root tolerance to alkaline pH, acid pH and aluminium ions. We propose that GABA exerts its multiple physiological effects in plants via ALMT, including the regulation of pollen tube and root growth, and that GABA can finally be considered a legitimate signalling molecule in both the plant and animal kingdoms.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.