Evidence map›Paper›PMID 26219399›Full record

ArticlePsychological medicine2015

Functional connectivity for face processing in individuals with body dysmorphic disorder and anorexia nervosa.

T D Moody, M A Sasaki, C Bohon, M A Strober, S Y Bookheimer, C L Sheen, J D Feusner

Abstract read
In one paragraph

Article in Psychological medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. A systematic review of neurocognition and social cognition in body dysmorphic disorder.The Australian and New Zealand journal of psychiatry · 2025
    Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Perceptual Dysfunction in Eating Disorders.Current topics in behavioral neurosciences · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

T D MoodyPsychiatry and Biobehavioral Sciences, UCLA,Los Angeles,CA,USA.
M A SasakiPsychiatry and Biobehavioral Sciences, UCLA,Los Angeles,CA,USA.
C BohonPsychiatry and Biobehavioral Sciences, Stanford University School of Medicine,Stanford,CA,USA.
M A StroberPsychiatry and Biobehavioral Sciences, UCLA,Los Angeles,CA,USA.
S Y BookheimerPsychiatry and Biobehavioral Sciences, UCLA,Los Angeles,CA,USA.
C L SheenPsychiatry and Biobehavioral Sciences, UCLA,Los Angeles,CA,USA.
J D FeusnerPsychiatry and Biobehavioral Sciences, UCLA,Los Angeles,CA,USA.

Funding

TRAINING THE SCIENCE OF CHILD MENTAL HEALTH TREATMENTT32MH073517 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SUMA JACOB, John C. Piacentini · 2006 to 2026
$5.2M
Anxiety and reward interaction and prediction of outcomes in anorexia nervosaR01MH105662 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FEUSNER, JAMIE · 2015 to 2019
$2.3M
Common and Distinct Phenotypes of Body Dysmorphic Disorder and Anorexia NervosaR01MH093535 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FEUSNER, JAMIE · 2011 to 2015
$2.0M
Body Dysmorphic Disorder: clinical and neurobiological featuresK23MH079212 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FEUSNER, JAMIE · 2007 to 2011
$752k
NIMH NIH HHS 2T32MH073517NIMH NIH HHS 5K23MH079212NIMH NIH HHS K23 MH079212NIMH NIH HHS R01 MH093535NIMH NIH HHS R01MH093535NIMH NIH HHS R01 MH105662NIMH NIH HHS T32 MH073517
6 · The paper itself

Abstract

backgroundBody dysmorphic disorder (BDD) and anorexia nervosa (AN) are both characterized by distorted perception of appearance. Previous studies in BDD suggest abnormalities in visual processing of own and others' faces, but no study has examined visual processing of faces in AN, nor directly compared the two disorders in this respect.

methodWe collected functional magnetic resonance imaging data on 60 individuals of equivalent age and gender in each of three groups--20 BDD, 20 weight-restored AN, and 20 healthy controls (HC)--while they viewed images of others' faces that contained only high or low spatial frequency information (HSF or LSF). We tested hypotheses about functional connectivity within specialized sub-networks for HSF and LSF visual processing, using psychophysiological interaction analyses.

resultsThe BDD group demonstrated increased functional connectivity compared to HC between left anterior occipital face area and right fusiform face area (FFA) for LSF faces, which was associated with symptom severity. Both BDD and AN groups had increased connectivity compared to HC between FFA and precuneous/posterior cingulate gyrus for LSF faces, and decreased connectivity between FFA and insula. In addition, we found that LSF connectivity between FFA and posterior cingulate gyrus was significantly associated with thoughts about own appearance in AN.

conclusionsResults suggest similar abnormal functional connectivity within higher-order systems for face processing in BDD and AN, but distinct abnormal connectivity patterns within occipito-temporal visual networks. Findings may have implications for understanding relationships between these disorders, and the pathophysiology underlying perceptual distortions.

Indexed as

Facial RecognitionPerceptual DistortionAdolescentAdultAnorexia NervosaBody Dysmorphic DisordersCase-Control StudiesCerebral CortexFemaleHumansMagnetic Resonance ImagingMaleYoung AdultAnorexia nervosabody dysmorphic disorderfunctional connectivitypsychophysiological interaction

Identifiers

PMID26219399
PMCPMC4879882

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.