Evidence map›Paper›PMID 26218851›Full record

ReviewTranslational psychiatry2015

Immune and neurotrophin stimulation by electroconvulsive therapy: is some inflammation needed after all?

E M van Buel, K Patas, M Peters, F J Bosker, U L M Eisel, H C Klein

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Translational psychiatry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Changes in leukocytes and CRP in different treatments of major depression.Journal of neural transmission (Vienna, Austria : 1996) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

E M van Buel1] Department of Molecular Neurobiology, Center for Life Sciences, University of Groningen, Groningen, The Netherlands [2] Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
K Patas1] Department of Molecular Neurobiology, Center for Life Sciences, University of Groningen, Groningen, The Netherlands [2] Institute of Neuroimmunology and Multiple Sclerosis, Center for Molecular Neurobiology, University Medical Center Eppendorf, Hamburg, Germany.
M PetersDepartment of Molecular Neurobiology, Center for Life Sciences, University of Groningen, Groningen, The Netherlands.
F J BoskerDepartment of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
U L M Eisel1] Department of Molecular Neurobiology, Center for Life Sciences, University of Groningen, Groningen, The Netherlands [2] Department of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
H C Klein1] Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands [2] Department of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A low-grade inflammatory response is commonly seen in the peripheral blood of major depressive disorder (MDD) patients, especially those with refractory and chronic disease courses. However, electroconvulsive therapy (ECT), the most drastic intervention reserved for these patients, is closely associated with an enhanced haematogenous as well as neuroinflammatory immune response, as evidenced by both human and animal studies. A related line of experimental evidence further shows that inflammatory stimulation reinforces neurotrophin expression and may even mediate dramatic neurogenic and antidepressant-like effects following exposure to chronic stress. The current review therefore attempts a synthesis of our knowledge on the neurotrophic and immunological aspects of ECT and other electrically based treatments in psychiatry. Perhaps contrary to contemporary views, we conclude that targeted potentiation, rather than suppression, of inflammatory responses may be of therapeutic relevance to chronically depressed patients or a subgroup thereof.

Indexed as

Electroconvulsive TherapyHumansInflammationMajor Depressive DisorderNerve Growth FactorsTreatment OutcomeNerve Growth Factors

Identifiers

PMID26218851
PMCPMC5068722

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.