ArticleScientific reports2015
Mechanisms of hypervirulent Clostridium difficile ribotype 027 displacement of endemic strains: an epidemiological model.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 48 citations in OpenAlex.
- Extraintestinal Manifestations ofAntibiotics (Basel, Switzerland) · 2025Review
- Exploring the Toxin-Mediated Mechanisms inMicroorganisms · 2024Review
- Probiotics for Prevention and Treatment of Clostridium difficile Infection.Advances in experimental medicine and biology · 2024Article
- Changes in the Association Between Diagnostic Testing Method, Polymerase Chain Reaction Ribotype, and Clinical Outcomes From Clostridioides difficile Infection: One Institution's Experience.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Article
- Transition From PCR-Ribotyping to Whole Genome Sequencing Based Typing ofFrontiers in cellular and infection microbiology · 2021Article
- Faecal microbiota transplantation for Clostridioides difficile: mechanisms and pharmacology.Nature reviews. Gastroenterology & hepatology · 2021Review
- Curcumin: A natural derivative with antibacterial activity against Clostridium difficile.Journal of global antimicrobial resistance · 2020Article
- Aryl-alkyl-lysines: Novel agents for treatment of C. difficile infection.Scientific reports · 2020Article
- Heart Failure Is a Risk Factor for Suffering and Dying ofJournal of clinical medicine · 2020Article
- Mathematical modelling for antibiotic resistance control policy: do we know enough?BMC infectious diseases · 2019Article
- A global to local genomics analysis of Clostridioides difficile ST1/RT027 identifies cryptic transmission events in a northern Arizona healthcare network.Microbial genomics · 2019Article
- Whole Genome Sequencing for Surveillance of Diphtheria in Low Incidence Settings.Frontiers in public health · 2019Review
- Design and Expression of Specific Hybrid Lantibiotics Active Against PathogenicFrontiers in microbiology · 2019Article
- Review
- The Daniel K. Inouye College of Pharmacy Scripts: Updates onHawai'i journal of medicine & public health : a journal of Asia Pacific Medicine & Public Health · 2017Article
- An in silico evaluation of treatment regimens for recurrent Clostridium difficile infection.PloS one · 2017Article
- Community-Acquired Clostridium difficile Infection, Queensland, Australia.Emerging infectious diseases · 2016Article
- Secreted Compounds of the Probiotic Bacillus clausii Strain O/C Inhibit the Cytotoxic Effects Induced by Clostridium difficile and Bacillus cereus Toxins.Antimicrobial agents and chemotherapy · 2016Article
- Clostridium difficile infection: epidemiology, diagnosis and understanding transmission.Nature reviews. Gastroenterology & hepatology · 2016Review
- Effect of Bifidobacterium upon Clostridium difficile Growth and Toxicity When Co-cultured in Different Prebiotic Substrates.Frontiers in microbiology · 2016Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Following rapid, global clonal dominance of hypervirulent ribotypes, Clostridium difficile now constitutes the primary infectious cause of nosocomial diarrhoea. Evidence indicates at least three possible mechanisms of hypervirulence that facilitates the successful invasion of these atypical strains: 1) increased infectiousness relative to endemic strains; 2) increased symptomatic disease rate relative to endemic strains; and 3) an ability to outcompete endemic strains in the host's gut. Stochastic simulations of an infection transmission model demonstrate clear differences between the invasion potentials of C. difficile strains utilising the alternative hypervirulence mechanisms, and provide new evidence that favours certain mechanisms (1 and 2) more than others (3). Additionally, simulations illustrate that direct competition between strains (inside the host's gut) is not a prerequisite for the sudden switching that has been observed in prevailing ribotypes; previously dominant C. difficile strains can be excluded by hypervirulent ribotypes through indirect (exploitative) competition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.