ArticlePloS one2015
The Flagellar Arginine Kinase in Trypanosoma brucei Is Important for Infection in Tsetse Flies.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 29 citations in OpenAlex.
- Capsaicin, a Vanilloid Derivative, Modulates Arginine Kinase mRNA Expression in Trypanosoma evansi.Acta parasitologica · 2025Article
- Intraflagellar transport speed is sensitive to genetic and mechanical perturbations to flagellar beating.The Journal of cell biology · 2024Article
- Design, Synthesis, and Evaluation of An Anti-trypanosomal [1,2,4]Triazolo[1,5-a]pyrimidine Probe for Photoaffinity Labeling Studies.ChemMedChem · 2024Article
- Structure, function and druggability of the African trypanosome flagellum.Journal of cellular physiology · 2022Review
- Immunomodulatory effects of two recombinant arginine kinases inFrontiers in immunology · 2022Article
- Redistribution of FLAgellar Member 8 during the trypanosome life cycle: Consequences for cell fate prediction.Cellular microbiology · 2021Article
- Flagellar targeting of an arginine kinase requires a conserved lipidated protein intraflagellar transport (LIFT) pathway inThe Journal of biological chemistry · 2020Article
- Apoferritin and Apoferritin-Capped Metal Nanoparticles Inhibit Arginine Kinase ofMolecules (Basel, Switzerland) · 2020Article
- Defeating the trypanosomatid trio: proteomics of the protozoan parasites causing neglected tropical diseases.RSC medicinal chemistry · 2020Review
- A global analysis of low-complexity regions in theWellcome open research · 2020Article
- Natural Products Containing 'Rare' Organophosphorus Functional Groups.Molecules (Basel, Switzerland) · 2019Review
- The Uptake and Metabolism of Amino Acids, and Their Unique Role in the Biology of Pathogenic Trypanosomatids.Pathogens (Basel, Switzerland) · 2018Review
- The Lipid Raft Proteome of African Trypanosomes Contains Many Flagellar Proteins.Pathogens (Basel, Switzerland) · 2017Article
- Evolution of Cilia.Cold Spring Harbor perspectives in biology · 2017Review
- Two flagellar BAR domain proteins in Trypanosoma brucei with stage-specific regulation.Scientific reports · 2016Article
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
African trypanosomes are flagellated parasites that cause sleeping sickness. Parasites are transmitted from one mammalian host to another by the bite of a tsetse fly. Trypanosoma brucei possesses three different genes for arginine kinase (AK) including one (AK3) that encodes a protein localised to the flagellum. AK3 is characterised by the presence of a unique amino-terminal insertion that specifies flagellar targeting. We show here a phylogenetic analysis revealing that flagellar AK arose in two independent duplication events in T. brucei and T. congolense, the two species of African trypanosomes that infect the tsetse midgut. In T. brucei, AK3 is detected in all stages of parasite development in the fly (in the midgut and in the salivary glands) as well as in bloodstream cells, but with predominance at insect stages. Genetic knockout leads to a slight reduction in motility and impairs parasite infectivity towards tsetse flies in single and competition experiments, both phenotypes being reverted upon expression of an epitope-tagged version of AK3. We speculate that this flagellar arginine kinase is important for T. brucei infection of tsetse, especially in the context of mixed infections and that its flagellar targeting relies on a system equivalent to that discovered for calflagins, a family of trypanosome flagellum calcium binding proteins.
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