Evidence map›Paper›PMID 26218316›Full record

ReviewCurrent opinion in neurobiology2015

The molecules that mediate sensory transduction in the mammalian inner ear.

Bifeng Pan, Jeffrey R Holt

Abstract readReview
In one paragraph

Review in Current opinion in neurobiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Pharmacological Approaches to Hearing Loss.Pharmacological reviews · 2024
    Review
  2. Article
  3. Sensory Hair Cells: An Introduction to Structure and Physiology.Integrative and comparative biology · 2018
    Review
  4. Transmission Disrupted: Modeling Auditory Synaptopathy in Zebrafish.Frontiers in cell and developmental biology · 2018
    Review
  5. The genetics of hair-cell function in zebrafish.Journal of neurogenetics · 2017
    Review
  6. Are TMCs the Mechanotransduction Channels of Vertebrate Hair Cells?The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Bifeng PanDepartment of Otolaryngology, F.M. Kirby Neurobiology Center, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, United States.
Jeffrey R HoltDepartment of Otolaryngology, F.M. Kirby Neurobiology Center, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, United States. Electronic address: jeffrey.holt@childrens.harvard.edu.

Funding

TMC gene function in sensory hair cellsR01DC013521 · NIDCD · BOSTON CHILDREN'S HOSPITAL · PI JEFFREY R HOLT · 2013 to 2026
$6.0M
NIDCD NIH HHS R01 DC013521NIDCD NIH HHS R01-DC013521
6 · The paper itself

Abstract

Years of searching and researching have finally yielded a few leads in the quest to identify molecules required for mechanosensory transduction in the mammalian inner ear. Studies of human and mouse genetics have raised the profile of several molecules that are crucial for the function sensory hair cells. Follow up studies have begun to define the molecular function and biochemical interactions of several key proteins. These studies have exposed a sensory transduction apparatus that is more complex than originally envisioned and have reinvigorated the search for additional molecular components required for normal inner ear function.

Indexed as

MastodyniaAnimalsEar, InnerHearingHumansSensory Receptor CellsSignal Transduction

Identifiers

PMID26218316
PMCPMC4698977

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.