Evidence map›Paper›PMID 26218314›Full record

ArticleCancer biology & therapy2020

Expression and clinical implication of cyclooxygenase-2 and E-cadherin in oral squamous cell carcinomas.

Angela Santoro, Pantaleo Bufo, Giuseppe Russo, Simona Cagiano, Silvana Papagerakis, Paolo Bucci, Gabriella Aquino, Francesco Longo, Antonia Feola, Antonio Giordano and 3 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer biology & therapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 26 citations in OpenAlex.

  1. Therapeutic targeting of COX-2 in head and neck cancer: Mechanistic and clinical perspectives.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2026
    Review
  2. Chlorogenic acid suppresses angiogenesis in 4T1 breast tumorsResearch in pharmaceutical sciences · 2026
    Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Sirtuins and Hypoxia in EMT Control.Pharmaceuticals (Basel, Switzerland) · 2022
    Review
  11. Review
  12. Article
  13. Review
  14. Review
  15. Article
  16. Journal of oral microbiology · 2019
    Article
  17. Review
  18. Immunohistochemical expression of COX-2, Ki-67, Bcl-2, Bax, VEGF and CD105 according to histological grading in oral squamous cell carcinoma.Revista espanola de patologia : publicacion oficial de la Sociedad Espanola de Anatomia Patologica y de la Sociedad Espanola de Citologia
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 8 institutions in 2 countries.

Angela SantoroDepartment of Anatomic Pathology, 'Giovanni Paolo II' Foundation-UCSC , Campobasso, Italy.
Pantaleo BufoDepartment of Clinical and Experimental Medicine, Institute of Pathological Anatomy, University of Foggia , Foggia, Italy.
Giuseppe RussoDepartment of Clinical and Experimental Medicine, Institute of Pathological Anatomy, University of Foggia , Foggia, Italy.
Simona CagianoDepartment of Clinical and Experimental Medicine, Institute of Pathological Anatomy, University of Foggia , Foggia, Italy.
Silvana PapagerakisLaboratory of Head and Neck Cancer Invasion and Metastasis, Department of Otolaryngology, Head and Neck Oncology, University of Michigan, Medical School , Ann Arbor, MI, USA.
Paolo BucciDepartment of Neuroscience, Reproductive and Odontostomatologies Science, University of Naples 'Federico II' , Naples, Italy.
Gabriella AquinoSection of Pathological Anatomy, National Cancer Institute 'G. Pascale Foundation' , Naples, Italy.
Francesco LongoHead and Neck Medical Oncology Unit, National Cancer Institute 'G. Pascale Foundation' , Naples, Italy.
Antonia FeolaDepartment of Biology, University of Naples , Naples, Italy.
Antonio GiordanoDepartment of Medicine, Surgery and Neuroscience, University of Siena , Siena, Italy.
Angelina Di CarloDepartment of Medico-Surgical Sciences and Biotechnologies, "Sapienza" University of Rome , Rome, Italy.
Marina Di DomenicoDepartment of Biochemistry, Biophisic and General Pathology Second University of Naples , Naples, Italy.
Giuseppe PannoneDepartment of Clinical and Experimental Medicine, Institute of Pathological Anatomy, University of Foggia , Foggia, Italy.
University of Foggia · ITIstituto Nazionale Tumori IRCCS "Fondazione G. Pascale" · ITUniversity of Naples Federico II · ITIstituto Tumori Bari · ITSapienza University of Rome · ITUniversity of Campania "Luigi Vanvitelli" · ITUniversity of Michigan–Ann Arbor · USUniversity of Siena · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Epithelial-Mesenchymal Transition (EMT) and angiogenesis are crucial events for development of aggressive and often fatal Oral Squamous Cell Carcinomas (OSCCs). Both

Indexed as

AdultAgedAged, 80 and overCadherinsCarcinoma, Squamous CellCyclooxygenase 2HumansMiddle AgedMouth NeoplasmsTumor MicroenvironmentCadherinsCyclooxygenase 2CD-34Cox-2E-cadherinneo-angiogenesisOSCCProstaglandinsTMAtumor microenvironment

Identifiers

PMID26218314
PMCPMC7537792
OpenAlexW2097368906

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.