ArticleScientific reports2015
Comparison of stimulus-evoked cerebral hemodynamics in the awake mouse and under a novel anesthetic regime.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 54 citations in OpenAlex.
- Dopamine release-associated striatal blood oxygenation and whole-brain dynamics during associative learning.Science advances · 2026Article
- Nitric oxide is not responsible for initial sensory-induced neurovascular coupling response in the barrel cortex of lightly anesthetized mice.Neurophotonics · 2025Article
- High-resolution awake mouse fMRI at 14 tesla.eLife · 2025Article
- Characterizing vascular function in mouse models of Alzheimer's disease, atherosclerosis, and mixed Alzheimer's and atherosclerosis.Neurophotonics · 2025Article
- Voluntary locomotion induces an early and remote hemodynamic decrease in the large cerebral veins.Neurophotonics · 2025Article
- Hemodynamic and neuronal contributions to low-frequency vascular oscillations in a preclinical model of Alzheimer's disease.Neurophotonics · 2025Article
- Spatiotemporal relationships between neuronal, metabolic, and hemodynamic signals in the awake and anesthetized mouse brain.Cell reports · 2024Article
- High-resolution awake mouse fMRI at 14 Tesla.bioRxiv : the preprint server for biology · 2024Article
- Mesoscopic mapping of hemodynamic responses and neuronal activity during pharmacologically induced interictal spikes in awake and anesthetized mice.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Article
- Intrinsic, widefield optical imaging of hemodynamics in rodent models of Alzheimer's disease and neurological injury.Neurophotonics · 2023Review
- Generation of a whole-brain hemodynamic response function and sex-specific differences in cerebral processing of mechano-sensation in mice detected by BOLD fMRI.Frontiers in neuroscience · 2023Article
- The effects of locomotion on sensory-evoked haemodynamic responses in the cortex of awake mice.Scientific reports · 2022Article
- Behavioral and physiological monitoring for awake neurovascular coupling experiments: a how-to guide.Neurophotonics · 2022Article
- Optical measurement of microvascular oxygenation and blood flow responses in awake mouse cortex during functional activation.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022Article
- Article
- Male and Female C57BL/6 Mice Respond Differently to Awake Magnetic Resonance Imaging Habituation.Frontiers in neuroscience · 2022Article
- Differences in cerebral blood vasculature and flow in awake and anesthetized mouse cortex revealed by quantitative optical coherence tomography angiography.Journal of neuroscience methods · 2021Article
- Neurovascular coupling preserved in a chronic mouse model of Alzheimer's disease: Methodology is critical.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2020Article
- A longitudinal, multi-parametric functional MRI study to determine age-related changes in the rodent brain.NeuroImage · 2020Article
- Procedure and protocols for optical imaging of cerebral blood flow and hemodynamics in awake mice.Biomedical optics express · 2020Article
Corrections and comments
- Erratum issued
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Neural activity is closely followed by a localised change in cerebral blood flow, a process termed neurovascular coupling. These hemodynamic changes form the basis of contrast in functional magnetic resonance imaging (fMRI) and are used as a correlate for neural activity. Anesthesia is widely employed in animal fMRI and neurovascular studies, however anesthetics are known to profoundly affect neural and vascular physiology, particularly in mice. Therefore, we investigated the efficacy of a novel 'modular' anesthesia that combined injectable (fentanyl-fluanisone/midazolam) and volatile (isoflurane) anesthetics in mice. To characterize sensory-evoked cortical hemodynamic responses, we used optical imaging spectroscopy to produce functional maps of changes in tissue oxygenation and blood volume in response to mechanical whisker stimulation. Following fine-tuning of the anesthetic regime, stimulation elicited large and robust hemodynamic responses in the somatosensory cortex, characterized by fast arterial activation, increases in total and oxygenated hemoglobin, and decreases in deoxygenated hemoglobin. Overall, the magnitude and speed of evoked hemodynamic responses under anesthesia resembled those in the awake state, indicating that the novel anesthetic combination significantly minimizes the impact of anesthesia. Our findings have broad implications for both neurovascular research and longitudinal fMRI studies that increasingly require the use of genetically engineered mice.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.