Evidence map›Paper›PMID 26217794›Full record

ArticleData in brief2015

Integrated analysis of mRNA and miRNA expression in response to interleukin-6 in hepatocytes.

Samuel W Lukowski, Richard J Fish, Juliette Martin-Levilain, Carmen Gonelle-Gispert, Leo H Bühler, Pierre Maechler, Emmanouil T Dermitzakis, Marguerite Neerman-Arbez

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Data in brief, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Samuel W LukowskiDepartment of Genetic Medicine and Development, University of Geneva Medical School, 1211 Geneva, Switzerland ; Institute of Genetics and Genomics in Geneva (iGE3), 1211 Geneva, Switzerland.
Richard J FishDepartment of Genetic Medicine and Development, University of Geneva Medical School, 1211 Geneva, Switzerland ; Institute of Genetics and Genomics in Geneva (iGE3), 1211 Geneva, Switzerland.
Juliette Martin-LevilainDepartment of Cell Physiology and Metabolism, University of Geneva Medical Center, Geneva, Switzerland.
Carmen Gonelle-GispertSurgical Research Unit, Department of Surgery, University Hospital, 1211 Geneva, Switzerland.
Leo H BühlerSurgical Research Unit, Department of Surgery, University Hospital, 1211 Geneva, Switzerland.
Pierre MaechlerDepartment of Cell Physiology and Metabolism, University of Geneva Medical Center, Geneva, Switzerland.
Emmanouil T DermitzakisDepartment of Genetic Medicine and Development, University of Geneva Medical School, 1211 Geneva, Switzerland ; Institute of Genetics and Genomics in Geneva (iGE3), 1211 Geneva, Switzerland ; Swiss Institute of Bioinformatics, 1211 Geneva, Switzerland.
Marguerite Neerman-ArbezDepartment of Genetic Medicine and Development, University of Geneva Medical School, 1211 Geneva, Switzerland ; Institute of Genetics and Genomics in Geneva (iGE3), 1211 Geneva, Switzerland.
University of Geneva · CHUniversity Hospital of Geneva · CHSIB Swiss Institute of Bioinformatics · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Understanding the interactions between miRNAs and genes they regulate during the acute phase response is crucial to our understanding of inflammatory diseases and processes. Inducing the acute phase response in hepatocytes by stimulating them with interleukin-6 [1] and then examining global changes in mRNA and miRNA expression can provide insight into the timing and dynamics of these interactions. Here we provide additional data for our study, Ref. [2]. In this data, we identify and validate IL-6-induced changes in gene expression [3-6] and their functional relationships over time and between cell types by gene ontology [7,8]. We also provide data showing the enrichment of miRNA binding motifs in the 3׳UTRs of differentially expressed genes [9], and their predicted gene targets derived from our RNA-seq data [10].

Identifiers

PMID26217794
PMCPMC4510544
OpenAlexW2290274977

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.