ReviewFrontiers in plant science2015
Role of proline and pyrroline-5-carboxylate metabolism in plant defense against invading pathogens.
Review in Frontiers in plant science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers, 1 of them a synthesis that pooled it.
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Who cites it
66 citing papers in PubMed, 1 synthesis or guideline pooled it, 159 citations in OpenAlex.
- Meta-analysis of drought-tolerant genotypes in Oryza sativa: A network-based approach.PloS one · 2019Pooled it
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- Organic priming strategies enhance antioxidant defense and suppress corm rot in saffron: role of Trichoderma and walnut leaf powder.Protoplasma · 2026Article
- Quantification of Mitochondrial Pyrroline-5-Carboxylate in Arabidopsis Under Pseudomonas Syringae Infection.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Measurement of δMetabolites · 2025Article
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- Exogenous SNP Alleviates Drought Stress in Wheat During the Grain-Filling Stage by ModulatingInternational journal of molecular sciences · 2025Article
- Ornithine enhances common bean growth and defense against white mold disease via interfering withFrontiers in plant science · 2025Article
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- Genome-wide identification and expression analysis of proline synthesis and catabolism genes in kiwifruit: exploring the role ofFrontiers in plant science · 2025Article
- Drought-induced molecular changes in crown of various barley phytohormone mutants.Plant signaling & behavior · 2024Article
- Arvimicrobium flavum gen. nov., sp. nov., A Novel Genus in the Family Phyllobacteriaceae Isolated From Forest Soil.Current microbiology · 2024Article
- The nonphototrophic hypocotyl 3 (NPH3) domain protein NRL5 is a trafficking-associated GTPase essential for drought resistance.Science advances · 2024Article
- Longitudinal Transcriptomic, Proteomic, and Metabolomic Response ofJournal of proteome research · 2024Article
- ComparativeFoods (Basel, Switzerland) · 2024Article
- Plants interfere with non-self recognition of a phytopathogenic fungus via proline accumulation to facilitate mycovirus transmission.Nature communications · 2024Article
- Nitric Oxide Mitigates the Deleterious Effects Caused by Infection ofPlants (Basel, Switzerland) · 2024Article
6 more citing papers are in PubMed but not listed here.
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3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pyrroline-5-carboxylate (P5C) is an intermediate product of both proline biosynthesis and catabolism. Recent evidences indicate that proline-P5C metabolism is tightly regulated in plants, especially during pathogen infection and abiotic stress. However, role of P5C and its metabolism in plants has not yet been fully understood. Studies indicate that P5C synthesized in mitochondria has a role in both resistance (R)-gene-mediated and non-host resistance against invading pathogens. Proline dehydrogenase and delta-ornithine amino transferase-encoding genes, both involved in P5C synthesis in mitochondria are implicated in defense response of Nicotiana benthamiana and Arabidopsis thaliana against bacterial pathogens. Such defense response is proposed to involve salicylic acid-dependent pathway, reactive oxygen species (ROS) and hypersensitive response (HR)-associated cell death. Recently HR, a form of programmed cell death (PCD), has been proposed to be induced by changes in mitochondrial P5C synthesis or the increase in P5C levels per se in plants inoculated with either a host pathogen carrying suitable avirulent (Avr) gene or a non-host pathogen. Consistently, A. thaliana mutant plants deficient in P5C catabolism showed HR like cell death when grown in external P5C or proline supplemented medium. Similarly, yeast and plant cells under oxidative stress were shown to increase ROS production and PCD due to increase in P5C levels. Similar mechanism has also been reported as one of the triggers for apoptosis in mammalian cells. This review critically analyzes results from various studies and enumerates the pathways for regulation of P5C levels in the plant cell, especially in mitochondria, during pathogen infection. Further, mechanisms regulating P5C- mediated defense responses, namely HR are outlined. This review also provides new insights into the differential role of proline-P5C metabolism in plants exposed to pathogen infection.
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