ArticleFrontiers in immunology2015
Transcription Factor T-Bet in Atlantic Salmon: Characterization and Gene Expression in Mucosal Tissues during Aeromonas Salmonicida Infection.
Article in Frontiers in immunology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 21 citations in OpenAlex.
- Plasmid-DNA EncodedPharmaceutics · 2026Article
- Characterization and Vaccine Development ofVaccines · 2025Article
- Cellular responses in rainbow trout Oncorhynchus mykiss to experimental Anisakis simplex infection.Parasitology research · 2025Article
- Identification and Characterization of a Master Transcription Factor of Th1 Cells, T-bet, Within Flounder (Frontiers in immunology · 2021Article
- Overexpression of T-bet, GATA-3 and TGF-ß Induces IFN-γ, IL-4/13A, and IL-17A Expression in Atlantic Salmon.Biology · 2020Article
- Induction of IL-22 protein and IL-22-producing cells in rainbow trout Oncorhynchus mykiss.Developmental and comparative immunology · 2019Article
- Immunomodulatory Effects of Dietary Seaweeds in LPS Challenged Atlantic SalmonFrontiers in physiology · 2018Article
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The T-box transcription factor T-bet is expressed in a number of hematopoietic cell types in mammals and plays an essential role in the lineage determination of Th1 T-helper cells and is considered as an essential feature for both innate and adaptive immune responses in higher vertebrates. In the present study, we have identified and characterized the full-length Atlantic salmon T-bet cDNA (3502 bp). The putative primary structure of the polypeptide deduced from the cDNA sequence contained 612 aa, which possessed a T-box DNA binding domain. Phylogenetic study and gene synteny revealed it is as a homolog to mammalian T-bet. Quantitative PCR analysis of different tissues in healthy fish showed that salmon T-bet gene was highly expressed in spleen, followed by head kidney, and was expressed in intestine, skin, and liver at lower levels. Moreover, the time-dependent expression profile of T-bet, interferon gamma (IFNγ), interleukin-22 (IL-22), and natural killer enhancement factor in mucosal tissues during water-borne infection with live Aeromonas salmonicida, indicated the involvement of T-bet in mucosal immune response in Atlantic salmon.
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