ArticleFrontiers in microbiology2015
Crassostrea gigas mortality in France: the usual suspect, a herpes virus, may not be the killer in this polymicrobial opportunistic disease.
Article in Frontiers in microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed, 144 citations in OpenAlex.
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- To cohabit or inoculate? Testing the limits of microbiota transplantation in Manila clams.ISME communications · 2026Article
- Whole genome sequencing of hepatitis A virus: adapting Illumina protocols for foodborne investigation.NPJ science of food · 2025Article
- The ecology and evolution of microbial immune systems: a look on the wild vibrio side.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Review
- Article
- Environmental Conditions Associated with Four Index Cases of Pacific Oyster Mortality Syndrome (POMS) inAnimals : an open access journal from MDPI · 2024Article
- Temporal variations of bacterial and eukaryotic community in coastal waters-implications for aquaculture.Applied microbiology and biotechnology · 2024Article
- Cross-talk and mutual shaping between the immune system and the microbiota during an oyster's life.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- Elevated temperature and decreased salinity impacts on exogenousFrontiers in microbiology · 2024Article
- Temperature and microbe mediated impacts of the San Diego Bay ostreid herpesvirus (OsHV-1) microvariant on juvenile Pacific oysters.Sustainable microbiology · 2024Article
- Cooperation and cheating orchestrate Vibrio assemblages and polymicrobial synergy in oysters infected with OsHV-1 virus.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Understanding the Dynamic of POMS Infection and the Role of Microbiota Composition in the Survival of Pacific Oysters, Crassostrea gigas.Microbiology spectrum · 2022Article
- Phylogenomic diversity ofMicrobial genomics · 2022Article
- Functional Diversification of Oyster Big Defensins Generates Antimicrobial Specificity and Synergy against Members of the Microbiota.Marine drugs · 2022Article
- Early life microbial exposures shape the Crassostrea gigas immune system for lifelong and intergenerational disease protection.Microbiome · 2022Article
- Mapping the Green-Lipped Mussel (Perna canaliculus) Microbiome: A Multi-Tissue Analysis of Bacterial and Fungal Diversity.Current microbiology · 2022Article
- Synergistic Interaction of Low Salinity Stress WithFrontiers in immunology · 2022Article
- Genetic diversity and connectivity of the Ostreid herpesvirus 1 populations in France: A first attempt to phylogeographic inference for a marine mollusc disease.Virus evolution · 2022Article
- Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Successive disease outbreaks in oyster (Crassostrea gigas) beds in France have resulted in dramatic losses in production, and subsequent decline in the oyster-farming industry. Deaths of juvenile oysters have been associated with the presence of a herpes virus (OsHV-1 μvar) and bacterial populations of the genus Vibrio. Although the pathogenicity of OsHV-1 μvar, as well as several strains of Vibrio has been demonstrated by experimental infections, our understanding of the complexity of infections occurring in the natural environment remains limited. In the present study, we use specific-pathogen-free (SPF) oysters infected in an estuarine environment to study the diversity and dynamics of cultured microbial populations during disease expression. We observe that rapid Vibrio colonization followed by viral replication precedes oyster death. No correlation was found between the vibrio concentration and viral load in co-infected animals. We show that the quantity of viral DNA is a predictor of mortality, however, in the absence of bacteria, a high load of herpes virus is not sufficient to induce the full expression of the disease. In addition, we demonstrate that juvenile mortalities can occur in the absence of herpes virus, indicating that the herpes virus appears neither essential nor sufficient to cause juvenile deaths; whereas bacteria are necessary for the disease. Finally, we demonstrate that oysters are a reservoir of putative pathogens, and that the geographic origin, age, and cultivation method of oysters influence disease expression.
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