Evidence map›Paper›PMID 26217224›Full record

ReviewFrontiers in aging neuroscience2015

Components of a Mediterranean diet and their impact on cognitive functions in aging.

Sebastian Huhn, Shahrzad Kharabian Masouleh, Michael Stumvoll, Arno Villringer, A Veronica Witte

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in aging neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 5 pooled it
11.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 5 syntheses or guidelines pooled it, 97 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Sebastian HuhnDepartment of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences Leipzig, Germany.
Shahrzad Kharabian MasoulehDepartment of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences Leipzig, Germany.
Michael StumvollCollaborative Research Centre 1052 'Obesity Mechanisms', Subproject A1, Faculty of Medicine, University of Leipzig Leipzig, Germany ; IFB Adiposity Diseases, University of Leipzig Leipzig, Germany.
Arno VillringerDepartment of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences Leipzig, Germany ; Collaborative Research Centre 1052 'Obesity Mechanisms', Subproject A1, Faculty of Medicine, University of Leipzig Leipzig, Germany.
A Veronica WitteDepartment of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences Leipzig, Germany ; Collaborative Research Centre 1052 'Obesity Mechanisms', Subproject A1, Faculty of Medicine, University of Leipzig Leipzig, Germany.
Max Planck Institute for Human Cognitive and Brain Sciences · DELeipzig University · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAdhering to the Mediterranean diet (MeDi) is known to be beneficial with regard to many age-associated diseases including cardiovascular diseases and type 2 diabetes. Recent studies also suggest an impact on cognition and brain structure, and increasing effort is made to track effects down to single nutrients.

aimsWe aimed to review whether two MeDi components, i.e., long-chain omega-3 fatty acids (LC-n3-FA) derived from sea-fish, and plant polyphenols including resveratrol (RSV), exert positive effects on brain health in aging. CONTENT: We summarized health benefits associated with the MeDi and evaluated available studies on the effect of (1) fish-consumption and LC-n3-FA supplementation as well as (2) diet-derived or supplementary polyphenols such as RSV, on cognitive performance and brain structure in animal models and human studies. Also, we discussed possible underlying mechanisms.

conclusionA majority of available studies suggest that consumption of LC-n3-FA with fish or fishoil-supplements exerts positive effects on brain health and cognition in older humans. However, more large-scale randomized controlled trials are needed to draw definite recommendations. Considering polyphenols and RSV, only few controlled studies are available to date, yet the evidence based on animal research and first interventional human trials is promising and warrants further investigation. In addition, the concept of food synergy within the MeDi encourages future trials that evaluate the impact of comprehensive lifestyle patterns to help maintaining cognitive functions into old age.

Indexed as

brain structurecognitionmemoryomega-3 fatty acidsplasticitypolyphenolsresveratrol

Identifiers

PMID26217224
PMCPMC4495334
OpenAlexW1528033498

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.