ReviewFrontiers in computational neuroscience2015
Homeostatic role of heterosynaptic plasticity: models and experiments.
Review in Frontiers in computational neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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Who cites it
51 citing papers in PubMed, 107 citations in OpenAlex.
- Population sparseness determines strength of Hebbian plasticity for maximal memory lifetime in associative networks.PLoS computational biology · 2026Article
- Homeostatic Plasticity Enables Stable yet Tunable Neuronal Assemblies.bioRxiv : the preprint server for biology · 2026Article
- Locally balanced inhibition allows for robust learning of input-output associations in feedforward networks with Hebbian plasticity.Journal of computational neuroscience · 2026Article
- Heterosynaptic Interactions between the Dorsal and Ventral Hippocampus in Individual Medium Spiny Neurons of the Nucleus Accumbens Ventromedial Shell.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Dendritic heterosynaptic plasticity arises from calcium-based input learning.Communications biology · 2026Article
- Calcium-based synaptic and structural plasticity link pathological activity to synaptic reorganization in Parkinson's disease.Science advances · 2025Article
- β-Adrenergic Receptor Activation Modulates the Induction of Complex Spike-Dependent LTP by Regulating Multiple Forms of Heterosynaptic Plasticity.Hippocampus · 2025Article
- Synaptic plasticity rules driving representational shifting in the hippocampus.Nature neuroscience · 2025Article
- Biological detail and graph structure in network neuroscience.Frontiers in network physiology · 2025Review
- Synaptic weight dynamics underlying memory consolidation: Implications for learning rules, circuit organization, and circuit function.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Plasticity of Response Properties of Mouse Visual Cortex Neurons Induced by Optogenetic Tetanization In Vivo.Current issues in molecular biology · 2024Article
- Building a realistic, scalable memory model with independent engrams using a homeostatic mechanism.Frontiers in neuroinformatics · 2024Article
- Heterosynaptic plasticity-induced modulation of synapses.The journal of physiological sciences : JPS · 2023Review
- Synaptic self-organization of spatio-temporal pattern selectivity.PLoS computational biology · 2023Article
- Stability and learning in excitatory synapses by nonlinear inhibitory plasticity.PLoS computational biology · 2022Article
- Synaptic balancing: A biologically plausible local learning rule that provably increases neural network noise robustness without sacrificing task performance.PLoS computational biology · 2022Article
- Cortical Motion Perception Emerges from Dimensionality Reduction with Evolved Spike-Timing-Dependent Plasticity Rules.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Role of Sleep in Formation of Relational Associative Memory.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Natural-gradient learning for spiking neurons.eLife · 2022Article
- Learning as filtering: Implications for spike-based plasticity.PLoS computational biology · 2022Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Homosynaptic Hebbian-type plasticity provides a cellular mechanism of learning and refinement of connectivity during development in a variety of biological systems. In this review we argue that a complimentary form of plasticity-heterosynaptic plasticity-represents a necessary cellular component for homeostatic regulation of synaptic weights and neuronal activity. The required properties of a homeostatic mechanism which acutely constrains the runaway dynamics imposed by Hebbian associative plasticity have been well-articulated by theoretical and modeling studies. Such mechanism(s) should robustly support the stability of operation of neuronal networks and synaptic competition, include changes at non-active synapses, and operate on a similar time scale to Hebbian-type plasticity. The experimentally observed properties of heterosynaptic plasticity have introduced it as a strong candidate to fulfill this homeostatic role. Subsequent modeling studies which incorporate heterosynaptic plasticity into model neurons with Hebbian synapses (utilizing an STDP learning rule) have confirmed its ability to robustly provide stability and competition. In contrast, properties of homeostatic synaptic scaling, which is triggered by extreme and long lasting (hours and days) changes of neuronal activity, do not fit two crucial requirements for a hypothetical homeostatic mechanism needed to provide stability of operation in the face of on-going synaptic changes driven by Hebbian-type learning rules. Both the trigger and the time scale of homeostatic synaptic scaling are fundamentally different from those of the Hebbian-type plasticity. We conclude that heterosynaptic plasticity, which is triggered by the same episodes of strong postsynaptic activity and operates on the same time scale as Hebbian-type associative plasticity, is ideally suited to serve a homeostatic role during on-going synaptic plasticity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.