ArticleFrontiers in computational neuroscience2015
Direct and indirect spino-cerebellar pathways: shared ideas but different functions in motor control.
Article in Frontiers in computational neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 17 citations in OpenAlex.
- Effect of Transcranial Direct Current Stimulation Targeting Brain Regions Identified Through Voxel-Based Morphometry on One-Legged Standing Balance With Eyes Closed.Brain and behavior · 2026Trial
- Article
- Kinematics-based assessment of reaching and grasping movements in LRN ablated animals identifies a role for the LRN in endpoint stabilization and reach timing.bioRxiv : the preprint server for biology · 2026Article
- Article
- Structure of Long-Range Direct and Indirect Spinocerebellar Pathways as Well as Local Spinal Circuits Mediating Proprioception.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Control of Mammalian Locomotion by Somatosensory Feedback.Comprehensive Physiology · 2021Article
- Article
- Conserved genetic signatures parcellate cardinal spinal neuron classes into local and projection subsets.Science (New York, N.Y.) · 2021Article
- Graded Arrays of Spinal and Supraspinal V2a Interneuron Subtypes Underlie Forelimb and Hindlimb Motor Control.Neuron · 2018Article
- Neuronal activity and outcomes from thalamic surgery for spinocerebellar ataxia.Annals of clinical and translational neurology · 2018Article
- Transient Vestibulopathy in Wallenberg's Syndrome: Pathologic Analysis.Frontiers in neurology · 2017Article
- The lateral reticular nucleus; integration of descending and ascending systems regulating voluntary forelimb movements.Frontiers in computational neuroscience · 2015Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
The impressive precision of mammalian limb movements relies on internal feedback pathways that convey information about ongoing motor output to cerebellar circuits. The spino-cerebellar tracts (SCT) in the cervical, thoracic and lumbar spinal cord have long been considered canonical neural substrates for the conveyance of internal feedback signals. Here we consider the distinct features of an indirect spino-cerebellar route, via the brainstem lateral reticular nucleus (LRN), and the implications of this pre-cerebellar "detour" for the execution and evolution of limb motor control. Both direct and indirect spino-cerebellar pathways signal spinal interneuronal activity to the cerebellum during movements, but evidence suggests that direct SCT neurons are mainly modulated by rhythmic activity, whereas the LRN also receives information from systems active during postural adjustment, reaching and grasping. Thus, while direct and indirect spino-cerebellar circuits can both be regarded as internal copy pathways, it seems likely that the direct system is principally dedicated to rhythmic motor acts like locomotion, while the indirect system also provides a means of pre-cerebellar integration relevant to the execution and coordination of dexterous limb movements.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.