Evidence map›Paper›PMID 26217209›Full record

ArticleFrontiers in human neuroscience2015

Mixed effectiveness of rTMS and retraining in the treatment of focal hand dystonia.

Teresa J Kimberley, Rebekah L S Schmidt, Mo Chen, Dennis D Dykstra, Cathrin M Buetefisch

2 registry-linked trialsOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in human neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01738581 phase1 / phase2completednot on this map

Effectiveness of rTMS and Retraining in the Treatment of Focal Hand Dystonia

TypeinterventionalSponsorUniversity of MinnesotaRan2011 to 2015Enrolled9ConditionsFocal DystoniaArmsRepetitive Transcranial Magnetic Stimulation, Sensorimotor Retraining, Non-specific Therapy
NCT02957942 nacompletednot on this mapstarted 2017, after this paper: background citation

Repetitive Transcranial Magnetic Stimulation in Spasmodic Dysphonia

TypeinterventionalSponsorUniversity of MinnesotaRan2017 to 2018Enrolled20ConditionsSpasmodic Dysphonia, Laryngeal DystoniaArms1Hz repetitive transcranial magnetic stimulation (rTMS)
3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 40 citations in OpenAlex.

  1. Observational
  2. Review
  3. Article
  4. Beyond Pallidal or Subthalamic Deep Brain Stimulation to Treat Dystonia.Tremor and other hyperkinetic movements (New York, N.Y.) · 2024
    Review
  5. Review
  6. Suitability of Automated Writing Measures for Clinical Trial Outcome in Writer's Cramp.Movement disorders : official journal of the Movement Disorder Society · 2023
    Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. New modalities and directions for dystonia care.Journal of neural transmission (Vienna, Austria : 1996) · 2021
    Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Teresa J KimberleyProgram in Physical Therapy, Brain Plasticity Laboratory, Department of Physical Medicine and Rehabilitation, University of Minnesota Minneapolis, MN, USA.
Rebekah L S SchmidtProgram in Physical Therapy, Brain Plasticity Laboratory, Department of Physical Medicine and Rehabilitation, University of Minnesota Minneapolis, MN, USA.
Mo ChenProgram in Physical Therapy, Brain Plasticity Laboratory, Department of Physical Medicine and Rehabilitation, University of Minnesota Minneapolis, MN, USA.
Dennis D DykstraDepartment of Physical Medicine and Rehabilitation, University of Minnesota Minneapolis, MN, USA.
Cathrin M BuetefischDepartment of Neurology and Rehabilitation Medicine, Emory University Atlanta, GA, USA.
University of Minnesota · US

Funding

University of Minnesota Clinical and Translational Science Institute (UMN CTSI)UL1TR000114 · NCATS · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R · 2012 to 2015
$35.0M
Dystonia CoalitionU54NS065701 · NINDS · EMORY UNIVERSITY · PI JINNAH, HYDER A · 2009 to 2014
$7.0M
NCATS NIH HHS UL1 TR000114NINDS NIH HHS U54 NS065701
6 · The paper itself

Abstract

unlabelledThough the pathophysiology of dystonia remains uncertain, two primary factors implicated in the development of dystonic symptoms are excessive cortical excitability and impaired sensorimotor processing. The aim of this study was to determine the functional efficacy of an intervention combining repetitive transcranial magnetic stimulation (rTMS) and sensorimotor retraining. A randomized, single-subject, multiple baseline design with crossover was used to examine participants with focal hand dystonia (FHD) (n = 9).

intervention5 days rTMS + sensorimotor retraining (SMR) vs. Five days rTMS + control therapy (CTL) (which included stretching and massage). The rTMS was applied to the premotor cortex at 1 Hz at 80% resting motor threshold for 1200 pulses. For sensorimotor retraining, a subset of the Learning-based Sensorimotor Training program was followed. Each session in both groups consisted of rTMS followed immediately by 30 min of the therapy intervention (SMR or CTL). Contrary to our hypothesis, group analyses revealed no additional benefit from the SMR training vs. CTL. When analyzed across group however, there was significant improvement from the first baseline assessment in several measures, including tests of sensory ability and self-rated changes. The patient rated improvements were accompanied by a moderate effect size suggesting clinical meaningfulness. These results provide encouragement for further investigation of rTMS in FHD with a need to optimize a secondary intervention and determine likely responders vs. non-responders.

Indexed as

humanneuromodulationrehabilitationsensorytranscranial magnetic stimulationwriter's cramp

Identifiers

PMID26217209
PMCPMC4496570
OpenAlexW1891756794

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.