ArticleFrontiers in behavioral neuroscience2015
BDNF Val(66)Met and 5-HTTLPR Genotype are Each Associated with Visual Scanning Patterns of Faces in Young Children.
Article in Frontiers in behavioral neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 14 citations in OpenAlex.
- Developmental Foundations of Psychosocial Interventions in Pediatric Oncology: A Lifespan Framework for Resilience.Children (Basel, Switzerland) · 2026Review
- Emotion and Feeling in Parent-Child Dyads: Neurocognitive and Psychophysiological Pathways of Development.Children (Basel, Switzerland) · 2025Review
- Prognostic Value of FasL, BDNF, and IL-1β as Predictors of Therapeutic Response in Schizophrenia.Journal of clinical medicine · 2025Article
- Parent-Child Eye Gaze Congruency to Emotional Expressions Mediated by Child Aesthetic Sensitivity.Children (Basel, Switzerland) · 2025Article
- Social Affiliation and Attention to Angry Faces in Children: Evidence for the Contributing Role of Parental Sensory Processing Sensitivity.Children (Basel, Switzerland) · 2025Article
- Interaction effects of the 5-HTT and MAOA-uVNTR gene variants on pre-attentive EEG activity in response to threatening voices.Communications biology · 2022Article
- An integrative analysis of 5HTT-mediated mechanism of hyperactivity to non-threatening voices.Communications biology · 2020Article
- Differential effects of anxiety and autism on social scene scanning in males with fragile X syndrome.Journal of neurodevelopmental disorders · 2017Review
- Serotonin 5-HTTLPR Genotype Modulates Reactive Visual Scanning of Social and Non-social Affective Stimuli in Young Children.Frontiers in behavioral neuroscience · 2017Article
- Early event-related potentials to emotional faces differ for adults with autism spectrum disorder and by serotonin transporter genotype.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2016Article
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Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous studies have documented both neuroplasticity-related BDNF Val(66)Met and emotion regulation-related 5-HTTLPR polymorphisms as genetic variants that contribute to the processing of emotions from faces. More specifically, research has shown the BDNF Met allele and the 5-HTTLPR Short allele to be associated with mechanisms of negative affectivity that relate to susceptibility for psychopathology. We examined visual scanning pathways in response to angry, happy, and neutral faces in relation to BDNF Val(66)Met and 5-HTTLPR genotyping in 49 children aged 4-7 years. Analyses revealed that variations in the visual processing of facial expressions of anger interacted with BDNF Val(66)Met genotype, such that children who carried at least one low neuroplasticity Met allele exhibited a vigilance-avoidance pattern of visual scanning compared to homozygotes for the high neuroplasticity Val allele. In a separate investigation of eye gaze towards the eye versus mouth regions of neutral faces, we observed that short allele 5-HTTLPR carriers exhibited reduced looking at the eye region compared with those with the higher serotonin uptake Long allele. Together, these findings suggest that genetic mechanisms early in life may influence the establishment of patterns of visual scanning of environmental stressors, which in conjunction with other factors such as negative life events, may lead to psychological difficulties and disorders in the later adolescent and adult years.
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