ArticleProceedings of the National Academy of Sciences of the United States of America2015
Requirement of Fra proteins for communication channels between cells in the filamentous nitrogen-fixing cyanobacterium Anabaena sp. PCC 7120.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 28 citations in OpenAlex.
- Evolution of multicellularity genes in Cyanobacteria in the lead up to the great oxidation event.Communications biology · 2025Article
- The periplasmic and cytoplasmic faces of septal protein SepJ from filamentous cyanobacteria.Journal of bacteriology · 2025Review
- Nanoscale elemental and morphological imaging of nitrogen-fixing cyanobacteria.Metallomics : integrated biometal science · 2024Article
- Discovery of cyanophycin dipeptide hydrolase enzymes suggests widespread utility of the natural biopolymer cyanophycin.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Comparative Network Biology Discovers Protein Complexes That Underline Cellular Differentiation in Anabaena sp.Molecular & cellular proteomics : MCP · 2022Article
- Heterocyst Septa Contain Large Nanopores That Are Influenced by the Fra Proteins in the Filamentous CyanobacteriumJournal of bacteriology · 2021Article
- Loss of Filamentous Multicellularity inJournal of bacteriology · 2020Article
- The small CaBMC microbiology · 2020Article
- Article
- Cyanobacterial Septal Junctions: Properties and Regulation.Life (Basel, Switzerland) · 2018Review
- Specific mutations in the permease domain of septal protein SepJ differentially affect functions related to multicellularity in the filamentous cyanobacteriumMicrobial cell (Graz, Austria) · 2018Article
- Soft X-Ray Imaging of Cellular Carbon and Nitrogen Distributions in Heterocystous Cyanobacteria.Plant physiology · 2018Article
- Septal protein SepJ from the heterocyst-forming cyanobacteriumFEBS open bio · 2017Article
- Plasticity first: molecular signatures of a complex morphological trait in filamentous cyanobacteria.BMC evolutionary biology · 2017Article
- Specific Glucoside Transporters Influence Septal Structure and Function in the Filamentous, Heterocyst-Forming Cyanobacterium Anabaena sp. Strain PCC 7120.Journal of bacteriology · 2017Article
- Article
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Authors and funding
4 authors at 2 institutions in 2 countries.
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No grant is acknowledged in the PubMed record.
Abstract
The filamentous nitrogen-fixing cyanobacterium Anabaena sp. PCC 7120 differentiates specialized cells, heterocysts, that fix atmospheric nitrogen and transfer the fixed nitrogen to adjacent vegetative cells. Reciprocally, vegetative cells transfer fixed carbon to heterocysts. Several routes have been described for metabolite exchange within the filament, one of which involves communicating channels that penetrate the septum between adjacent cells. Several fra gene mutants were isolated 25 y ago on the basis of their phenotypes: inability to fix nitrogen and fragmentation of filaments upon transfer from N+ to N- media. Cryopreservation combined with electron tomography were used to investigate the role of three fra gene products in channel formation. FraC and FraG are clearly involved in channel formation, whereas FraD has a minor part. Additionally, FraG was located close to the cytoplasmic membrane and in the heterocyst neck, using immunogold labeling with antibody raised to the N-terminal domain of the FraG protein.
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