ArticleProceedings of the National Academy of Sciences of the United States of America2015
Gating of a mechanosensitive channel due to cellular flows.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Models of Cellular Mechanosensation.Results and problems in cell differentiation · 2026Review
- Effects of membrane viscoelasticity on the red blood cell dynamics in a microcapillary.Biophysical journal · 2023Article
- Elucidating the molecular basis of spontaneous activation in an engineered mechanosensitive channel.Computational and structural biotechnology journal · 2022Article
- Red blood cells under flow show maximal ATP release for specific hematocrit.Biophysical journal · 2021Article
- Microfluidic Based Physical Approaches towards Single-Cell Intracellular Delivery and Analysis.Micromachines · 2021Review
- Bottom-up synthetic biology: modular design for making artificial platelets.Physical biology · 2017Article
- Primary cilia: Cell and molecular mechanosensors directing whole tissue function.Seminars in cell & developmental biology · 2017Review
- Highly efficient genome editing of human hematopoietic stem cells via a nano-silicon-blade delivery approach.Integrative biology : quantitative biosciences from nano to macro · 2017Article
- Dynamics of Escherichia coli's passive response to a sudden decrease in external osmolarity.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
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Authors and funding
5 authors.
Funding
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Abstract
A multiscale continuum model is constructed for a mechanosensitive (MS) channel gated by tension in a lipid bilayer membrane under stresses due to fluid flows. We illustrate that for typical physiological conditions vesicle hydrodynamics driven by a fluid flow may render the membrane tension sufficiently large to gate a MS channel open. In particular, we focus on the dynamic opening/closing of a MS channel in a vesicle membrane under a planar shear flow and a pressure-driven flow across a constriction channel. Our modeling and numerical simulation results quantify the critical flow strength or flow channel geometry for intracellular transport through a MS channel. In particular, we determine the percentage of MS channels that are open or closed as a function of the relevant measure of flow strength. The modeling and simulation results imply that for fluid flows that are physiologically relevant and realizable in microfluidic configurations stress-induced intracellular transport across the lipid membrane can be achieved by the gating of reconstituted MS channels, which can be useful for designing drug delivery in medical therapy and understanding complicated mechanotransduction.
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