ArticleProceedings of the National Academy of Sciences of the United States of America2015
Orthologs of the archaeal isopentenyl phosphate kinase regulate terpenoid production in plants.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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37 citing papers in PubMed, 98 citations in OpenAlex.
- Terpenoids fromPlants (Basel, Switzerland) · 2026Review
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- Light Quantity Impacts Early Response to Cold and Cold Acclimation in Young Leaves of Arabidopsis.Plant, cell & environment · 2025Article
- Progress and prospects in metabolic engineering approaches for isoprenoid biosynthesis in microalgae.Biotechnology for biofuels and bioproducts · 2025Review
- Investigation of Growth and Ginsenoside Content of Wild-Simulated Ginseng Cultivated in Different Vegetation Environments for Establishing a Plant Growth Model.Plants (Basel, Switzerland) · 2025Article
- Characterization of Volatile Compounds and Odorants in Different Sichuan Pepper Varieties in Tallow Hotpot.Foods (Basel, Switzerland) · 2025Article
- Efficient accumulation of new irregular monoterpene malonyl glucosides inFrontiers in plant science · 2025Article
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- Molecular Regulatory Mechanisms Affecting Fruit Aroma.Foods (Basel, Switzerland) · 2024Review
- Plant Engineering to Enable Platforms for Sustainable Bioproduction of Terpenoids.Methods in molecular biology (Clifton, N.J.) · 2024Review
- Farnesyl pyrophosphate compartmentalization in the green microalga Chlamydomonas reinhardtii during heterologous (E)-α-bisabolene production.Microbial cell factories · 2022Article
- Pathway Engineering, Re-targeting, and Synthetic Scaffolding Improve the Production of Squalene in Plants.ACS synthetic biology · 2022Article
- Duplication and Specialization of NUDX1 in Rosaceae Led to Geraniol Production in Rose Petals.Molecular biology and evolution · 2022Article
- Alternative metabolic pathways and strategies to high-titre terpenoid production inNatural product reports · 2022Review
- Article
- Isoprenoid biosynthesis regulation in poplars by methylerythritol phosphate and mevalonic acid pathways.Frontiers in plant science · 2022Article
- Multi-omics analysis the differences of VOCs terpenoid synthesis pathway in maintaining obligate mutualism betweenFrontiers in plant science · 2022Article
- Environmental and Genetic Factors Involved in Plant Protection-Associated Secondary Metabolite Biosynthesis Pathways.Frontiers in plant science · 2022Review
- Review
- Novel Homologs of Isopentenyl Phosphate Kinase Reveal Class-Wide Substrate Flexibility.ChemCatChem · 2021Article
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Authors and funding
5 authors at 3 institutions in 1 country.
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Abstract
Terpenoids, compounds found in all domains of life, represent the largest class of natural products with essential roles in their hosts. All terpenoids originate from the five-carbon building blocks, isopentenyl diphosphate (IPP) and its isomer dimethylallyl diphosphate (DMAPP), which can be derived from the mevalonic acid (MVA) and methylerythritol phosphate (MEP) pathways. The absence of two components of the MVA pathway from archaeal genomes led to the discovery of an alternative MVA pathway with isopentenyl phosphate kinase (IPK) catalyzing the final step, the formation of IPP. Despite the fact that plants contain the complete classical MVA pathway, IPK homologs were identified in every sequenced green plant genome. Here, we show that IPK is indeed a member of the plant terpenoid metabolic network. It is localized in the cytosol and is coexpressed with MVA pathway and downstream terpenoid network genes. In planta, IPK acts in parallel with the MVA pathway and plays an important role in regulating the formation of both MVA and MEP pathway-derived terpenoid compounds by controlling the ratio of IP/DMAP to IPP/DMAPP. IP and DMAP can also competitively inhibit farnesyl diphosphate synthase. Moreover, we discovered a metabolically available carbon source for terpenoid formation in plants that is accessible via IPK overexpression. This metabolite reactivation approach offers new strategies for metabolic engineering of terpenoid production.
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