ArticlePediatrics2015
Thrombocytopenia in Small-for-Gestational-Age Infants.
Article in Pediatrics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Article
- Thrombocytopenia in preterm infants born to mothers with systemic lupus erythematosus: a retrospective cohort study.Clinical and experimental pediatrics · 2026Article
- Development and implementation of restrictive platelet transfusion thresholds in a neonatal intensive care unit.Journal of perinatology : official journal of the California Perinatal Association · 2025Article
- Prevalence and associated factors of thrombocytopenia among neonates in Northwest Amhara region comprehensive specialized hospitals, Ethiopia: a cross sectional study.Scientific reports · 2025Article
- Distinct protein patterns related to postnatal development in small for gestational age preterm infants.Pediatric research · 2025Article
- Effects of pre-eclampsia/eclampsia on platelet parameters in small for gestational age preterm infants.Frontiers in pediatrics · 2025Article
- Prevalence and determinants of thrombocytopenia in newborn unit at Alexandria University Hospital: a three-year report including 1000 patients.BMC pediatrics · 2024Observational
- Hemostatic Profile of Intrauterine Growth-Restricted Neonates: Assessment with the Use of NATEM Assay in Cord Blood Samples.Diagnostics (Basel, Switzerland) · 2024Article
- Thrombocytopenia and insufficient thrombopoietin production in human small-for-gestational-age infants.Pediatric research · 2023Article
- The association of insufficient gestational weight gain in women with gestational diabetes mellitus with adverse infant outcomes: A case-control study.Frontiers in public health · 2023Article
- The effects of maternal hypertension on the early neonatal platelet count.Journal of perinatology : official journal of the California Perinatal Association · 2022Article
- Thrombocytopenia as Type 1 ROP Biomarker: A Longitudinal Study.Journal of personalized medicine · 2021Article
- Severe retinopathy of prematurity is associated with early post-natal low platelet count.Scientific reports · 2021Article
- Aberrant Hematopoiesis and Morbidity in Extremely Preterm Infants With Intrauterine Growth Restriction.Frontiers in pediatrics · 2021Article
- Expressions of Fib, IL-12 in Serum of Neonatal Necrotizing Enterocolitis and Their Correlation with Clinicopathological Features.Iranian journal of public health · 2020Article
- Article
- Thromboelastometry: studying hemostatic profile in small for gestational age neonates-a pilot observational study.European journal of pediatrics · 2019Observational
- Neonatal thrombocytopenia-causes and outcomes following platelet transfusions.European journal of pediatrics · 2018Article
- Developmental differences between newborn and adult mice in response to romiplostim.Platelets · 2018Article
- The immature platelet fraction: creating neonatal reference intervals and using these to categorize neonatal thrombocytopenias.Journal of perinatology : official journal of the California Perinatal Association · 2017Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundThrombocytopenia is common among small-for-gestational-age (SGA) neonates (birth weight <10th percentile reference range), but several aspects of this thrombocytopenia are unclear, including the incidence, typical nadir, duration, association with preeclampsia, mechanism, and risk of death.
methodsUsing 9 years of multihospital records, we studied SGA neonates with ≥2 platelet counts <150,000/μL in their first week.
resultsWe found first-week thrombocytopenia in 31% (905 of 2891) of SGA neonates versus 10% of non-SGA matched controls (P < .0001). Of the 905, 102 had a recognized cause of thrombocytopenia (disseminated intravascular coagulation, early-onset sepsis, or extracorporeal membrane oxygenation). This group had a 65% mortality rate. The remaining 803 did not have an obvious cause for their thrombocytopenia, and we called this "thrombocytopenia of SGA." They had a mortality rate of 2% (P < .0001) and a mean nadir count on day 4 of 93,000/μL (SD 51,580/μL, 10th percentile 50,000/μL, 90th percentile 175,000/μL). By day 14, platelet counts were ≥150,000/μL in more than half of the patients. Severely SGA neonates (<1st percentile) had lower counts and longer thrombocytopenia duration (P < .001). High nucleated red cell counts at birth correlated with low platelets (P < .0001). Platelet transfusions were given to 23%, and counts typically more than tripled. Thrombocytopenia was more associated with SGA status than with the diagnosis of maternal preeclampsia.
conclusionsSGA neonates with clearly recognized varieties of thrombocytopenia have a high mortality rate. In contrast, thrombocytopenia of SGA is a hyporegenerative condition of moderate severity and 2 weeks' duration and is associated with evidence of intrauterine hypoxia and a low mortality rate.
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