Evidence map›Paper›PMID 26216249›Full record

ArticleJournal of abnormal child psychology2015

Variation in Parasympathetic Dysregulation Moderates Short-term Memory Problems in Childhood Attention-Deficit/Hyperactivity Disorder.

Anthony R Ward, Gabriela Alarcón, Joel T Nigg, Erica D Musser

RetractedErratum issuedOpen access · greenAbstract read
In one paragraph

Article in Journal of abnormal child psychology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
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  6. Review
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  8. Article
  9. Physical health in children with neurodevelopmental disorders.Journal of autism and developmental disorders · 2019
    Article
  10. Parent Emotion Expression and Autonomic-Linked Emotion Dysregulation in Childhood ADHD.Journal of psychopathology and behavioral assessment · 2018
    Article
  11. Article
  12. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Anthony R WardCenter for Children and Families, Department of Psychology, Florida International University, 11200 SW 8th St., AHC 4 455, Miami, FL, 33199, USA. arward@fiu.edu.ORCID http://orcid.org/0000-0002-6606-5574
Gabriela AlarcónDepartment of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR, USA.
Joel T NiggDepartment of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR, USA.
Erica D MusserCenter for Children and Families, Department of Psychology, Florida International University, 11200 SW 8th St., AHC 4 455, Miami, FL, 33199, USA.
Florida Department of Children and Families · USOregon Health & Science University · US

Funding

BIOLOGICAL BASES OF ALCOHOLISMT32AA007468 · NIAAA · OREGON HEALTH & SCIENCE UNIVERSITY · PI Andrey E Ryabinin · 1987 to 2026
$11.3M
ADHD heterogeneity, mechanisms, and risk profileR37MH059105 · NIMH · OREGON HEALTH & SCIENCE UNIVERSITY · PI NIGG, JOEL T · 2014 to 2023
$7.0M
NEUROPSYCHOLOGICAL AND FAMILIAL MARKERS FOR CHILD ADHDR01MH059105 · NIMH · OREGON HEALTH & SCIENCE UNIVERSITY · PI NIGG, JOEL T · 1999 to 2012
$3.3M
NIAAA NIH HHS T32 AA007468NIMH NIH HHS R01 MH059105NIMH NIH HHS R01-MH59105NIMH NIH HHS R37 MH059105
6 · The paper itself

Abstract

Although attention deficit/hyperactivity disorder (ADHD) is associated with impairment in working memory and short-term memory, up to half of individual children with ADHD perform within a normative range. Heterogeneity in other ADHD-related mechanisms, which may compensate for or combine with cognitive weaknesses, is a likely explanation. One candidate is the robustness of parasympathetic regulation (as indexed by respiratory sinus arrhythmia; RSA). Theory and data suggest that a common neural network is likely tied to both heart-rate regulation and certain cognitive functions (including aspects of working and short-term memory). Cardiac-derived indices of parasympathetic reactivity were collected during short-term memory (STM) storage and rehearsal tasks from 243 children (116 ADHD, 127 controls). ADHD was associated with lower STM performance, replicating previous work. In addition, RSA reactivity moderated the association between STM and ADHD - both as a category and a dimension - independent of comorbidity. Specifically, conditional effects revealed that high levels of withdrawal interacted with weakened STM but high levels of augmentation moderated a positive association predicting ADHD. Thus, variations in parasympathetic reactivity may help explain neuropsychological heterogeneity in ADHD.

Indexed as

Attention Deficit Disorder with HyperactivityAutonomic Nervous System DiseasesChildFemaleHumansMaleMemory DisordersMemory, Short-TermRespiratory Sinus ArrhythmiaAttention-deficit/hyperactivity disorderExecutive functionPsychophysiologyRSAWorking memory

Identifiers

PMID26216249
PMCPMC4625793
OpenAlexW2150651678

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.