Evidence map›Paper›PMID 26215904›Full record

Trial reportInternational urogynecology journal2015

Lower urinary tract symptoms after subtotal versus total abdominal hysterectomy: exploratory analyses from a randomized clinical trial with a 14-year follow-up.

Lea Laird Andersen, Lars Mikael Alling Møller, Helga Gimbel, Danish Hysterectomy Trial Group

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in International urogynecology journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01880710 (Randomized Clinical Trial of Total Versus Subtotal Abdominal Hysterectomy), which is not on this map. Cited by 5 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 2 pooled it
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01880710 nacompletednot on this map

Randomized Clinical Trial of Total Versus Subtotal Abdominal Hysterectomy

TypeinterventionalSponsorNykøbing Falster County HospitalRan2012 to 2014Enrolled319ConditionsBenign Uterine DiseaseArmsSubtotal hysterectomy, Total Hysterectomy
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 2 syntheses or guidelines pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Lea Laird AndersenDepartment of Obstetrics and Gynecology, Nykøbing Falster Hospital, Nykøbing Falster, Denmark. lealairdandersen@gmail.com.
Lars Mikael Alling MøllerDepartment of Obstetrics and Gynecology, Roskilde Hospital, Roskilde, Denmark.
Helga GimbelDepartment of Obstetrics and Gynecology, Nykøbing Falster Hospital, Nykøbing Falster, Denmark.
Danish Hysterectomy Trial Group
Sjællands Universitetshospital, Nykøbing F. · DKRoskilde Sygehus · DKUniversity of Southern Denmark · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introduction and hypothesisLower urinary tract symptoms (LUTS) are common after hysterectomy and increase after menopause. We aimed to compare subtotal with total abdominal hysterectomy regarding LUTS, including urinary incontinence (UI) subtypes, 14 years after hysterectomy. Main results from this randomized clinical trial have been published previously; the analyses covered in this paper are exploratory.

methodsWe performed a long-term questionnaire follow-up of women in a randomized clinical trial (n = 319), from 1996 to 2000 comparing subtotal with total abdominal hysterectomy. Of the randomized women, ten had died and five had left Denmark; 304 women were contacted. For univariate analyses, a χ(2)-test was used, and for multivariate analyses, we used logistic regression.

resultsThe questionnaire was answered by 197 (64.7 %) women (subtotal 97; total 100). More women had subjective stress UI (SUI) in the subtotal group (n = 60; 62.5 %) compared with the total group (n = 45; 45 %), with a relative risk (RR) of 1.39 [95 % confidence interval (CI) 1.06-1.81; P = 0.014]. No difference was seen between subtotal and total abdominal hysterectomy in other LUTS. Factors associated with UI were UI prior to hysterectomy, local estrogen treatment, and body mass index (BMI) > 25 kg/m(2). High BMI was primarily associated with mixed UI (MUI) and urgency symptoms. Predictors of bothersome LUTS were UI and incomplete bladder emptying.

conclusionsThe difference in the frequency of subjectively assessed UI between subtotal and total abdominal hysterectomy (published previously) is caused by a difference in subjectively assessed SUI; UI prior to hysterectomy and high BMI are related to UI 14 years after hysterectomy.

trial registrationThe trial is registered on clinicaltrials.gov under Nykoebing Falster County Hospital Record sj-268: Total versus subtotal hysterectomy: http://clinicaltrials.gov/ct2/show/NCT01880710?term=hysterectomy&rank=27.

Indexed as

AdultBody Mass IndexDenmarkFemaleFollow-Up StudiesHumansHysterectomyLogistic ModelsLower Urinary Tract SymptomsMiddle AgedSurveys and QuestionnairesTime FactorsBMIHysterectomyLong-term outcomesLUTSSubtotal versus totalUrinary incontinence

Identifiers

PMID26215904
OpenAlexW1026116119

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.