ReviewSeminars in nephrology2015
Opportunities and Challenges of Genotyping Patients With Nephrotic Syndrome in the Genomic Era.
Review in Seminars in nephrology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 15 citations in OpenAlex.
- Promises and pitfalls of whole-exome sequencing exemplified by a nephrotic syndrome family.Molecular genetics and genomics : MGG · 2020Article
- TARGETING TARGETED TREATMENT FOR IMMUNE AND NON-IMMUNE KIDNEY DISEASES.Transactions of the American Clinical and Climatological Association · 2019Article
- An eQTL Landscape of Kidney Tissue in Human Nephrotic Syndrome.American journal of human genetics · 2018Article
- The status quo and challenges of genetic diagnosis in children with steroid-resistant nephrotic syndrome.World journal of pediatrics : WJP · 2018Article
- Calcium/Calmodulin Kinase IV Controls the Function of Both T Cells and Kidney Resident Cells.Frontiers in immunology · 2018Review
- Elevated urinary CRELD2 is associated with endoplasmic reticulum stress-mediated kidney disease.JCI insight · 2017Article
- The Democratization of Genomic Inquiry Empowers Our Understanding of Nephrotic Syndrome.Transplantation · 2017Article
- Genetics of hereditary nephrotic syndrome: a clinical review.Korean journal of pediatrics · 2017Review
- Podocyte-actin dynamics in health and disease.Nature reviews. Nephrology · 2016Review
- Using Population Genetics to Interrogate the Monogenic Nephrotic Syndrome Diagnosis in a Case Cohort.Journal of the American Society of Nephrology : JASN · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Both targeted and genome-wide linkage and association studies have identified a number of genes and genetic variants associated with nephrotic syndrome (NS). Genotype-phenotype studies of patients with these variants have identified correlations of clear clinical significance. Combined with improved genomic technologies, this has resulted in increasing, and justifiable, enthusiasm for incorporating our patients' genomic information into our clinical management decisions. Here, we summarize our understanding of NS-associated genetic factors, namely rare causal mutations or common risk alleles in apolipoprotein L1. We discuss the complexities inherent in trying to ascribe risk or causality to these variants, particularly as we seek to extend genetic testing to a broader group of patients, including many with sporadic disease. Overall, the thoughtful application and interpretation of these genetic tests will maximize the benefits to our patients with NS in the form of more precise clinical care.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.