SynthesisBMC neurology2015
D-dimer for the exclusion of cerebral venous thrombosis: a meta-analysis of low risk patients with isolated headache.
Synthesis in BMC neurology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Design-related bias in studies investigating diagnostic tests for venous thromboembolic diseases: a systematic review and meta-analysis.Frontiers in cardiovascular medicine · 2024Pooled it
- Use of D-dimer to Screen for Cerebral Pathology in ED Patients with Non-traumatic Headache and Normal Neurological Exam.The western journal of emergency medicine · 2026Observational
- Enhancing risk prediction for cerebral venous thrombosis: evaluation of an integrated approach with clinical CVT probability score and D-dimer levels.BMC neurology · 2026Article
- Clinical Profile of Patients Admitted With Venous Thrombosis to a Tertiary Care Hospital in India.Cureus · 2026Article
- An Unusual Case of Cerebral Venous Sinus Thrombosis With Negative D-dimer Mimicking Giant Cell Arteritis.Cureus · 2025Article
- A retrospective cohort study on a novel marker to predict the severity and prognosis of acute cerebral venous thrombosis: D-dimer to fibrinogen ratio.Thrombosis journal · 2024Article
- Endothelial receptor proteins in acute venous thrombosis and delayed thrombus resolution in cerebral sinus vein thrombosis.Journal of neurology · 2024Article
- How we manage a high D-dimer.Haematologica · 2024Review
- The Utility of Quantitative D-Dimer Assay as a Biomarker in the Diagnosis and Exclusion of Cerebral Venous Sinus Thrombosis.Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion · 2024Article
- Potential role of plasma branched-chain amino acids in the differential diagnosis of acute cerebral venous thrombosis.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023Article
- C-reactive protein and D-dimer in cerebral vein thrombosis: Relation to clinical and imaging characteristics as well as outcomes in a French cohort study.Research and practice in thrombosis and haemostasis · 2023Article
- Clinical Characteristics and Prognostic Factors of Non-Infectious Cerebral Venous Sinus Thrombosis.Journal of clinical medicine · 2022Article
- The diagnostic utility of unenhanced computed tomography of the brain and D-dimer levels in acute cerebral venous sinus thrombosis: A quantitative study.Journal of clinical imaging science · 2022Article
- Diagnostic and Therapeutic Challenges of Cerebral Venous Thrombosis in SARS-CoV-2 Infection: A Case Report and Review of Literature.Clinics and practice · 2021Article
- New Horizons for Diagnostic Pitfalls of Cerebral Venous Thrombosis: Clinical Utility of a Newly Developed Cerebral Venous Thrombosis Diagnostic Score: A Case Report and Literature Review.The American journal of case reports · 2021Review
- Predictive Value of Combination of D-dimer and Fibrinogen in Diagnosing Acute CVST.Annals of neurosciences · 2021Article
- Pathogenesis and Management in Cerebrovenous Outflow Disorders.Aging and disease · 2021Review
- D-Dimer Level Associates with the Incidence of Focal Neurological Deficits in Cerebral Venous Thrombosis Patients.Journal of blood medicine · 2020Article
- Cerebral Venous Thrombosis Headache.Current pain and headache reports · 2019Review
- [Cerebral venous and sinus thrombosis : S2k guidelines].Der Nervenarzt · 2019Review
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4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundPatients with isolated headache may have cerebral venous thrombosis (CVT). D-dimers are proven sensitive in excluding deep venous thrombosis (DVT) and pulmonary embolism (PE) in low risk patients. We aimed to determine whether D-dimer may play the same role in low risk CVT patients with isolated headache.
methodsWe included consecutive patients suspected of CVT from our teaching hospital with isolated headache, a normal neurological examination and normal standard head CT in whom D-dimer was determined. Additionally we did a systematic review on articles describing consecutive patients suspected of CVT with isolated headache and their D-dimer values. CVT was investigated with CT or MR venography in all patients.
resultsA total of 636 consecutive patients were collected from our own data and the literature search. Of 45 CVT patients one had a negative D-dimer (7.5 %). Sensitivity of D-dimer for diagnosing CVT was 97.8 % (95 % CI: 88.2-99.6 %), specificity was 84.9 % (95 % CI: 81.8-87.7 %), positive predictive value was 33.1 % (95 % CI: 25.2-41.7 %), negative predictive value was 99.8 % (95 % CI: 98.9-100 %). Another 56 isolated headache CVT patients were identified in literature, lacking consecutive isolated headache controls. Sensitivity of D-dimer for diagnosing CVT including these patients was 87.1 % (95 % CI: 79.0-93.0 %).
conclusionsD-dimers have a high negative predictive value in patients with isolated headache for excluding CVT. Sensitivity is lower but comparable to the values accepted in PE and DVT. Low risk patients were defined as headache patients with a normal neurological examination, normal standard head CT and absence of risk factors such as pregnancy or puerperium. Normal D-dimers in these patients may reduce unnecessary imaging, making it a potential valuable marker.
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