ArticleIntensive care medicine experimental2015
Prone position ameliorates lung elastance and increases functional residual capacity independently from lung recruitment.
Article in Intensive care medicine experimental, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Surviving sepsis campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children.Intensive care medicine · 2020Guideline
- Semirecumbent Positioning During Anesthesia Recovery and Postoperative Hypoxemia: A Randomized Clinical Trial.JAMA network open · 2024Trial
- [Effect of prone positioning on respiratory function in very preterm infants undergoing mechanical ventilation].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2018Trial
- Comparison of Postoperative Oxygenation and Dorsal Lung Ventilation in Patients Undergoing Craniotomy in Different Positions: Pulmonary Electrical Impedance Tomography Monitoring.Medical science monitor : international medical journal of experimental and clinical research · 2026Article
- [Prone positioning for acute respiratory distress syndrome in adults : Update on the physiological effects, indications and implementation].Die Anaesthesiologie · 2024Review
- Estimation of normal lung weight index in healthy female domestic pigs.Intensive care medicine experimental · 2024Article
- An appraisal of lung computer tomography in very early anti-inflammatory treatment of two different ovine ARDS phenotypes.Scientific reports · 2024Article
- Prone Positioning and Molecular Biomarkers in COVID and Non-COVID ARDS: A Narrative Review.Journal of clinical medicine · 2024Review
- Deriving Regionally Specific Biomarkers of Emphysema and Small Airways Disease Using Variable Threshold Parametric Response Mapping on Volumetric Lung CT Images.Academic radiology · 2022Article
- Altered responses of end-expiratory lung volume and upper airway patency to body posture in diet-induced obese mice.Physiological reports · 2021Article
- Broad individual immersion-scattering of respiratory compliance likely substantiates dissimilar breathing mechanics.Scientific reports · 2021Article
- Positional Therapy and Regional Pulmonary Ventilation.Anesthesiology · 2020Article
- Management of critically ill patients with COVID-19 in ICU: statement from front-line intensive care experts in Wuhan, China.Annals of intensive care · 2020Review
- A quantitative CT parameter for the assessment of pulmonary oedema in patients with acute respiratory distress syndrome.PloS one · 2020Observational
- Positional effects on the distributions of ventilation and end-expiratory gas volume in the asymmetric chest-a quantitative lung computed tomographic analysis.Intensive care medicine experimental · 2018Article
- Lung volumes and lung volume recruitment in ARDS: a comparison between supine and prone position.Annals of intensive care · 2018Article
- Prone position in patients with acute respiratory distress syndrome.Revista Brasileira de terapia intensivaReview
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundProne position is used to recruit collapsed dependent lung regions during severe acute respiratory distress syndrome, improving lung elastance and lung gas content. We hypothesised that, in the absence of recruitment, prone position would not result in any improvement in lung mechanical properties or gas content compared to supine position.
methodsTen healthy pigs under general anaesthesia and paralysis underwent a pressure-volume curve of the respiratory system, chest wall and lung in supine and prone positions; the respective elastances were measured. A lung computed tomography (CT) scan was performed in the two positions to compute gas content (i.e. functional residual capacity (FRC)) and the distribution of aeration. Recruitment was defined as a percentage change in non-aerated lung tissue compared to the total lung weight.
resultsNon-aerated (recruitable) lung tissue was a small percentage of the total lung tissue weight in both positions (4 ± 3 vs 1 ± 1 %, supine vs prone, p = 0.004). Lung elastance decreased (20.5 ± 1.8 vs 15.5 ± 1.6 cmH2O/l, supine vs prone, p < 0.001) and functional residual capacity increased (380 ± 82 vs 459 ± 60 ml, supine vs prone, p = 0.025) in prone position; specific lung elastance did not change (7.0 ± 0.5 vs 6.5 ± 0.5 cmH2O, supine vs prone, p = 0.24). Lung recruitment was low (3 ± 2 %) and was not correlated to increases in functional residual capacity (R (2) 0.2, p = 0.19). A higher amount of well-aerated and a lower amount of poorly aerated lung tissue were found in prone position.
conclusionsIn healthy pigs, prone position ameliorates lung mechanical properties and increases functional residual capacity independently from lung recruitment, through a redistribution of lung aeration.
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Registered trials
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