ArticleDiagnostic pathology2015
FusionCancer: a database of cancer fusion genes derived from RNA-seq data.
Article in Diagnostic pathology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed.
- A Practical Compass to Biological Digital Resources and Omics Integration in Ewing Sarcoma.Methods in molecular biology (Clifton, N.J.) · 2027Article
- Computational Prediction of Chimeric RNAs from Long Reads Using CTAT-LR-Fusion.Methods in molecular biology (Clifton, N.J.) · 2026Article
- PUM1-TRAF3 fusion protein activates non-canonical NF-κB signaling via rescued NIK in biliary tract cancer.NPJ precision oncology · 2024Article
- Beyond traditional translation: ncRNA derived peptides as modulators of tumor behaviors.Journal of biomedical science · 2024Review
- Comparison of the classifiers based on mRNA, microRNA and lncRNA expression and DNA methylation profiles for the tumor origin detection.Frontiers in genetics · 2024Article
- Structural variant analysis of a cancer reference cell line sample using multiple sequencing technologies.Genome biology · 2022Article
- GraphChrom: A Novel Graph-Based Framework for Cancer Classification Using Chromosomal Rearrangement Endpoints.Cancers · 2022Article
- Article
- Weighted gene co-expression network analysis reveals prognostic and diagnostic significance ofJournal of gastrointestinal oncology · 2022Article
- Identification andJournal of thoracic disease · 2022Article
- Clinically relevant fusion oncogenes: detection and practical implications.Therapeutic advances in medical oncology · 2022Review
- Identification of Crucial lncRNAs for Luminal A Breast Cancer through RNA Sequencing.International journal of endocrinology · 2022Article
- Screening for differentially expressed circRNAs in ischemic stroke by RNA sequencing.BMC neurology · 2021Article
- Identification of the cross-strand chimeric RNAs generated by fusions of bi-directional transcripts.Nature communications · 2021Article
- New insight into long non-coding RNAs associated with bone metastasis of breast cancer based on an integrated analysis.Cancer cell international · 2021Article
- Expression and gene regulation network of TYMS and BCL2L1 in colorectal cancer based on data mining.PeerJ · 2021Article
- A competing endogenous RNA network reveals key lncRNAs associated with sepsis.Molecular genetics & genomic medicine · 2021Article
- Identification of Biomarkers Related to Immune Cell Infiltration with Gene Coexpression Network in Myocardial Infarction.Disease markers · 2021Article
- Downregulated Expression of CLEC9A as Novel Biomarkers for Lung Adenocarcinoma.Frontiers in oncology · 2021Article
- Screening lncRNAs with diagnostic and prognostic value for human stomach adenocarcinoma based on machine learning and mRNA-lncRNA co-expression network analysis.Molecular genetics & genomic medicine · 2020Article
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5 authors.
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Abstract
backgroundFusion genes are chimeric results originated from previous separate genes with aberrant functions. The resulting protein products may lead to abnormal status of expression levels, functions and action sites, which in return may cause the abnormal proliferation of cells and cancer development.
resultsWith the emergence of next-generation sequencing technology, RNA-seq has spurred gene fusion discovery in various cancer types. In this work, we compiled 591 recently published RNA-seq datasets in 15 kinds of human cancer, and the gene fusion events were comprehensively identified. Based on the results, a database was developed for gene fusion in cancers (FusionCancer), with the attempt to provide a user-friendly utility for the cancer research community. A flexible query engine has been developed for the acquisition of annotated information of cancer fusion genes, which would help users to determine the chimera events leading to functional changes. FusionCancer can be accessible at the following hyperlink website: http://donglab.ecnu.edu.cn/databases/FusionCancer/
conclusionTo the best of our knowledge, FusionCancer is the first comprehensive fusion gene database derived only from cancer RNA-seq data.
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