ReviewCell calcium2015
The STIM1-ORAI1 microdomain.
Review in Cell calcium, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
56 citing papers in PubMed, 1 synthesis or guideline pooled it, 94 citations in OpenAlex.
- A bibliometric and visualization analysis of entosis research from 2007 to 2024.Frontiers in oncology · 2024Pooled it
- Recursive feedback between Piezo1 conformation and membrane mechanics drives self-organization into finite clusters.bioRxiv : the preprint server for biology · 2026Article
- Specialized cortical ER architecture modulates CaiScience · 2026Article
- Optical single-channel recording of CRAC channels with HaloTag and a CabioRxiv : the preprint server for biology · 2026Article
- Exploring the Role of Gut Microbiota and Probiotics in Acute Pancreatitis: A Comprehensive Review.International journal of molecular sciences · 2025Review
- Ca2+ tunneling architecture and function are important for secretion.The Journal of cell biology · 2025Article
- The Molecular Biology of Placental Transport of Calcium to the Human Foetus.International journal of molecular sciences · 2025Review
- Phospholipid scrambling induced by an ion channel/metabolite transporter complex.Nature communications · 2024Article
- SOCE as a regulator of neuronal activity.The Journal of physiology · 2024Review
- Computational insights in cell physiology.Frontiers in systems biology · 2024Review
- The bioelectric mechanisms of local calcium dynamics in cancer cell proliferation: an extension of the A549Frontiers in molecular biosciences · 2024Article
- Article
- Orai1 is an Entotic CaAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- T cell CaFrontiers in immunology · 2023Review
- CRAC and SK Channels: Their Molecular Mechanisms Associated with Cancer Cell Development.Cancers · 2022Review
- Blockage of Orai1-Nucleolin interaction meditated calcium influx attenuates breast cancer cells growth.Oncogenesis · 2022Article
- The Role of Lipids in CRAC Channel Function.Biomolecules · 2022Review
- PLXND1-mediated calcium dyshomeostasis impairs endocardial endothelial autophagy in atrial fibrillation.Frontiers in physiology · 2022Article
- Three-Dimensional Model of Sub-Plasmalemmal CaFrontiers in molecular biosciences · 2022Article
- Spatiotemporal regulation of store-operated calcium entry in cancer metastasis.Biochemical Society transactions · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
The regulatory protein STIM1 controls gating of the Ca(2+) channel ORAI1 by a direct protein-protein interaction. Because STIM1 is anchored in the ER membrane and ORAI1 is in the plasma membrane, the STIM-ORAI pathway can support Ca(2+) influx only where the two membranes come into close apposition, effectively demarcating a microdomain for Ca(2+) signalling. This review begins with a brief summary of the STIM-ORAI pathway of store-operated Ca(2+) influx, then turns to the special geometry of the STIM-ORAI microdomain and the expected characteristics of the microdomain Ca(2+) signal. A final section of the review seeks to place the STIM-ORAI microdomain into a broader context of cellular Ca(2+) signalling.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.