ArticleDevelopmental cognitive neuroscience2015
Earlier adolescent substance use onset predicts stronger connectivity between reward and cognitive control brain networks.
Article in Developmental cognitive neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 2 syntheses or guidelines pooled it, 82 citations in OpenAlex.
- The brain in social context: A systematic review of substance use and social processing from adolescence to young adulthood.Developmental cognitive neuroscience · 2022Pooled it
- Balancing act: Neural correlates of affect dysregulation in youth depression and substance use - A systematic review of functional neuroimaging studies.Developmental cognitive neuroscience · 2020Pooled it
- Brain regulation training improves emotional competences in patients with alcohol use disorder.Social cognitive and affective neuroscience · 2024Trial
- Risk Perception and Susceptibility to Peer Influence Predict Substance Use in Early Adolescence: Findings From the ABCD Study.Journal of studies on alcohol and drugs · 2026Article
- Association of HIV infection and alcohol use on resting-state functional connectivity and mental health in youth living with perinatal HIV.Research square · 2026Article
- Risk calculation circuit abnormalities plus psychosocial risk variables predict problematic substance use in youth with externalizing disorders.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Adolescent substance use trajectories are associated with nucleus accumbens functional connectivity.Journal of psychopharmacology (Oxford, England) · 2025Article
- Salience network resting-state functional connectivity predicts self-controlled decision-making.Scientific reports · 2025Article
- Neural Signatures of Cognitive Control Predict Future Adolescent Substance Use Onset and Frequency.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025Article
- Network state dynamics underpin basal craving in a transdiagnostic population.Molecular psychiatry · 2025Article
- Functional Brain Connectivity Predictors of Prospective Substance Use Initiation and Their Environmental Correlates.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025Article
- Nucleus Accumbens Resting State Functional Connectivity is Linked to Family Income, Reward Salience, and Substance Use.Journal of cellular neuroscience · 2025Article
- The influence of negative events on adolescents' mobile phone addiction: the chain mediating role of personality traits and emotional regulation style.Frontiers in psychiatry · 2025Article
- Functional brain connectivity predictors of prospective substance use initiation and their environmental correlates.medRxiv : the preprint server for health sciences · 2024Article
- Frontoparietal functional connectivity moderates the link between time spent on social media and subsequent negative affect in daily life.Scientific reports · 2023Article
- Network state dynamics underpin craving in a transdiagnostic population.medRxiv : the preprint server for health sciences · 2023Article
- The age-varying effects of adolescent stress on impulsivity and sensation seeking.Journal of research on adolescence : the official journal of the Society for Research on Adolescence · 2023Article
- Reduced connectivity of the cognitive control neural network at rest in young adults who had their first drink of alcohol prior to age 18.Psychiatry research. Neuroimaging · 2023Article
- Evaluating instrumental learning and striatal-cortical functional connectivity in adolescent alcohol and cannabis use.Addiction biology · 2023Article
- Structure-function coupling within the reward network in preschool children predicts executive functioning in later childhood.Developmental cognitive neuroscience · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
backgroundEarly adolescent onset of substance use is a robust predictor of future substance use disorders. We examined the relation between age of substance use initiation and resting state functional connectivity (RSFC) of the core reward processing (nucleus accumbens; NAcc) to cognitive control (prefrontal cortex; PFC) brain networks.
methodAdolescents in a longitudinal study of Mexican-origin youth reported their substance use annually from ages 10 to 16 years. At age 16, 69 adolescents participated in a resting state functional magnetic resonance imaging scan. Seed-based correlational analyses were conducted using regions of interest in bilateral NAcc.
resultsThe earlier that adolescents initiated substance use, the stronger the connectivity between bilateral NAcc and right dorsolateral PFC, right dorsomedial PFC, right pre-supplementary motor area, right inferior parietal lobule, and left medial temporal gyrus. DISCUSSION: The regions that demonstrated significant positive linear relationships between the number of adolescent years using substances and connectivity with NAcc are nodes in the right frontoparietal network, which is central to cognitive control. The coupling of reward and cognitive control networks may be a mechanism through which earlier onset of substance use is related to brain function over time, a trajectory that may be implicated in subsequent substance use disorders.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.