Evidence map›Paper›PMID 26215402›Full record

ArticleNeurocritical care2016

Association of Extubation Failure and Functional Outcomes in Patients with Acute Neurologic Illness.

Muhammad Adeel Rishi, Rahul Kashyap, Gregory Wilson, Louis Schenck, Sara Hocker

Abstract read
PubMed Publisher
In one paragraph

Article in Neurocritical care, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Treating postextubation dysphagia after stroke with pharyngeal electrical stimulation -insights from a randomized controlled pilot trial.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
    Trial
  3. Trial
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  5. Article
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  8. Perioperative Predictors of Extubation Failure and the Effect on Clinical Outcome After Infratentorial Craniotomy.Medical science monitor : international medical journal of experimental and clinical research · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Muhammad Adeel RishiMultidisciplinary Epidemiological and Translational Research in Critical Care Medicine (METRIC), Mayo Clinic, 200 First St SW, Rochester, MN, 55905, USA. rishi.muhammad@mayo.edu.
Rahul KashyapMultidisciplinary Epidemiological and Translational Research in Critical Care Medicine (METRIC), Mayo Clinic, 200 First St SW, Rochester, MN, 55905, USA.
Gregory WilsonMultidisciplinary Epidemiological and Translational Research in Critical Care Medicine (METRIC), Mayo Clinic, 200 First St SW, Rochester, MN, 55905, USA.
Louis SchenckDivision of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, USA.
Sara HockerDivision of Critical Care Neurology, Mayo Clinic, Rochester, MN, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAn association between extubation failure and neurologic and functional outcomes in patients with primary neurologic illness has not been investigated rigorously. We plan to conduct a retrospective chart review to study this association.

methodsA total of 949 unique patients intubated and ventilated for at least 48 h in Neuro ICU (NICU) were obtained. Extubation failure was defined as need for reintubation within 48 h of initial extubation. Independent and dependent association between extubation failure and clinical parameters was assessed.

resultsThe patients had a median age [interquartile range (IQR)] of 58.5 (23.0) years. 60.5% were male and 81.9% were Caucasian. Extubation failure occurred in 108 (12.8%) patients. There was no difference in age, APACHE 3 score, FOUR score, or GCS score of patients at ICU admission between those who experienced extubation failure and those who did not. Extubation failure was associated with longer NICU and hospital LOS [median (IQR); 13.7 (11.3) vs. 9.1(8.2) days, P < 0.01 and 24.5 (20.0) vs. 16.8 (16.7) days, P < 0.01]. Patients with extubation failure had worse functional outcomes at 6 months as measured by the modified Rankin score [MRS; median (IQR), 5.0 (2.0) vs. 4.0 (3.0), P < 0.01]. After adjusting for confounders, extubation failure was associated with longer hospital and ICU LOS and worse functional outcomes.

conclusionsIn patients with acute neurological illness, extubation failure is associated with longer ICU and hospital stays but does not impact hospital mortality. Patients with extubation failure may experience a worsening of their functional status over time.

Indexed as

Intubation, IntratrachealOutcome Assessment, Health CareRespiration, ArtificialAcute DiseaseAdultAgedFemaleHumansMaleMiddle AgedNervous System DiseasesRetreatmentRetrospective StudiesExtubation failureMechanical ventilationNeurological ICUReintubationRespiratory failure

Identifiers

PMID26215402

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.