ArticleNature communications2015
The iBeetle large-scale RNAi screen reveals gene functions for insect development and physiology.
Article in Nature communications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers.
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Who cites it
87 citing papers in PubMed.
- Mixed Evidence that Dosage Sensitive Genes Drive Global Dosage Compensation in Flour Beetles.Genome biology and evolution · 2026Article
- A model system test of trophic transmission of RNA interference effects using the milkweed bug Oncopeltus fasciatus (Hemiptera).Scientific reports · 2026Article
- BeetleAtlas 2: An enhanced Tribolium castaneum web resource for tissue and developmental transcriptomics allowing refinement of gene predictions.PLoS computational biology · 2026Article
- Microfluidic process-property correlations of dsRNA lipid nanoparticle formulations.Scientific reports · 2026Article
- Article
- Variability in mountain pine beetle (Coleoptera: Curculionidae) gene expression in response to increasing concentrations of species-specific double-stranded RNA.Journal of insect science (Online) · 2026Article
- Fifty high-content light sheet fluorescence microscopy datasets of Tribolium castaneum embryogenesis.Scientific data · 2025Article
- Orthologous genes of the red flour beetle Tribolium castaneum and the vinegar fly Drosophila melanogaster.BMC genomic data · 2025Article
- Odorant Binding Proteins inInsects · 2025Review
- Real-time imaging on a microwell device allows first insights into the embryonic development of the ubiquitous and notorious scabies parasite.Scientific reports · 2025Article
- Article
- In the Spotlight-Established Researcher.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2025Article
- Spatiotemporal segmentation of contraction waves in the extra-embryonic membranes of the red flour beetle.BMC bioinformatics · 2025Article
- Article
- The quest for the best target genes for RNAi-mediated pest control.Insect molecular biology · 2025Review
- Context-dependent coordination of movement in Tribolium castaneum larvae.The Journal of experimental biology · 2025Article
- Superior target genes and pathways for RNAi-mediated pest control revealed by genome-wide analysis in the beetle Tribolium castaneum.Pest management science · 2025Article
- De novo transcriptome assembly and differential gene expression analysis in different developmental stages of Agriotes sputator (click beetle).Scientific reports · 2024Article
- Deciphering a Beetle Clock: Individual and Sex-Dependent Variation in Daily Activity Patterns.Journal of biological rhythms · 2024Article
- Temporal control of RNAi reveals both robust and labile feedback loops in the segmentation clock of the red flour beetle.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
27 more citing papers are in PubMed but not listed here.
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Authors and funding
33 authors.
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Abstract
Genetic screens are powerful tools to identify the genes required for a given biological process. However, for technical reasons, comprehensive screens have been restricted to very few model organisms. Therefore, although deep sequencing is revealing the genes of ever more insect species, the functional studies predominantly focus on candidate genes previously identified in Drosophila, which is biasing research towards conserved gene functions. RNAi screens in other organisms promise to reduce this bias. Here we present the results of the iBeetle screen, a large-scale, unbiased RNAi screen in the red flour beetle, Tribolium castaneum, which identifies gene functions in embryonic and postembryonic development, physiology and cell biology. The utility of Tribolium as a screening platform is demonstrated by the identification of genes involved in insect epithelial adhesion. This work transcends the restrictions of the candidate gene approach and opens fields of research not accessible in Drosophila.
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