ReviewJournal of clinical hypertension (Greenwich, Conn.)2016
Polypharmacy in Older Adults With Hypertension: A Comprehensive Review.
Review in Journal of clinical hypertension (Greenwich, Conn.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 74 citations in OpenAlex.
- Combining angiotensin receptor blockers with chlorthalidone or hydrochlorothiazide - which is the better alternative? A meta-analysis.Systematic reviews · 2020Pooled it
- Low-Dose TEL/AML/CHTD SPC Versus Standard-Dose TEL in Hypertension: Phase III RCT.Hypertension (Dallas, Tex. : 1979) · 2026Trial
- Antihypertensive therapy in diabetes mellitus: efficacy, safety, and metabolic impacts in type 1 and type 2 diabetes.Cardiovascular diabetology. Endocrinology reports · 2026Review
- Association between polypharmacy and hypertension in the Iranian population aged 50 years or older: Iranian Multicenter Osteoporosis Study (IMOS-2021).BMC primary care · 2025Article
- Review
- Association of polypharmacy with clinical outcomes and healthcare utilization in older adults with cardiometabolic diseases: a retrospective cohort study.International journal of clinical pharmacy · 2025Article
- Impact of Multimorbidity on Symptom Burden and Symptom Clusters in Patients Receiving Chemotherapy.Cancer medicine · 2025Article
- Article
- Adverse Drug Reactions of Cardiovascular Classes of Medicines-Data for Bulgarian Population.Biomedicines · 2024Article
- Knowledge and acceptance associated with medication adherence among hypertension individuals in Aceh province, Indonesia.Heliyon · 2024Article
- Prevalence of Polypharmacy of Older People in a Large Brazilian Urban Center and its Associated Factors.International journal of environmental research and public health · 2023Article
- Vascular frailty, a proposal for new frailty type: A narrative review.The Kaohsiung journal of medical sciences · 2023Review
- Association between Polypharmacy and Cardiovascular Autonomic Function among Elderly Patients in an Urban Municipality Area of Kolkata, India: A Record-Based Cross-Sectional Study.Geriatrics (Basel, Switzerland) · 2022Article
- Analysis of the regional difference in the number of multi-drug prescriptions and its predictors in Japan, 2015-2018.BMC research notes · 2021Article
- A Japan nationwide web-based survey of estimation on patients for renal denervation based on blood pressure level and the number of antihypertensives (J-NEEDs survey).Journal of clinical hypertension (Greenwich, Conn.) · 2021Article
- State and Regional Variation in Prescription- and Payment-Related Promoters of Adherence to Blood Pressure Medication.Preventing chronic disease · 2020Article
- Prevalence, awareness, treatment, and control of hypertension in older people: results from the population-based KORA-age 1 study.BMC public health · 2020Article
- Ingestible Sensors and Medication Adherence: Focus on Use in Serious Mental Illness.Pharmacy (Basel, Switzerland) · 2020Review
- Hypertension and Drug Adherence in the Elderly.Frontiers in cardiovascular medicine · 2020Review
- Vasodilation Elicited by Isoxsuprine, Identified by High-Throughput Virtual Screening of Compound Libraries, Involves Activation of the NO/cGMP and H₂S/KMolecules (Basel, Switzerland) · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Older adults are more likely to take more than two medications for medical conditions, and polypharmacy is associated with increased risk of adverse events (fall injury, hyperkalemia and hypokalemia, heart failure, and blood pressure exacerbation), polypharmacy mismanagement, drug-drug interaction, and increased costs. Knowledge of drugs that interact with known antihypertensive agents is paramount to avoiding or reducing adverse events, hospitalizations, and health care dollars. Innovative approaches such as use of a fixed-dose combination pill, ingestible sensor system, electronic reminder system, medical audits, and the integration of a pharmacist in the care of patients should be implemented to avoid polypharmacy mismanagement.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.