ArticleAnnals of surgical oncology2016
Defining a Valid Age Cutoff in Staging of Well-Differentiated Thyroid Cancer.
Article in Annals of surgical oncology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
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Who cites it
58 citing papers in PubMed.
- Prognostic factors evaluated in differentiated thyroid carcinomas.Endocrine connections · 2026Review
- The extent of extranodal extension as a prognostic indicator in papillary thyroid cancer.Archives of endocrinology and metabolism · 2025Article
- Predictive factors for failure in patients with N1b papillary thyroid carcinoma.World journal of surgical oncology · 2025Article
- A Clinical Nomogram to Predict Survival Outcomes in Patients with Well-Differentiated Thyroid Cancer.Thyroid : official journal of the American Thyroid Association · 2025Article
- Surgical management and outcomes of T4a papillary thyroid carcinoma: a single-centre study of 602 cases.Endocrine · 2025Article
- Optimal cut-off age for AJCC staging system in Middle Eastern differentiated thyroid cancer.Frontiers in endocrinology · 2025Article
- Analysis of the clonal origin and differences in the biological behavior of multifocal papillary thyroid carcinoma.Oncology letters · 2024Article
- Prognostic factors of papillary and follicular carcinomas based on pre-, intra-, and post-operative findings.European thyroid journal · 2024Review
- Analysis of the ideal cutoff age as a predictor of differentiated thyroid cancer using the Surveillance, Epidemiology, and End Results database.Translational cancer research · 2024Article
- Multi-omics data analysis reveals the complex roles of age in differentiated thyroid cancer.Heliyon · 2024Article
- Clinical-Pathological Features of Thyroid Neoplasms in Young Patients Diagnosed in a Single Center.Life (Basel, Switzerland) · 2024Article
- Geriatric Importance of Histopathological Parameters Evaluated in Thyroidectomy Specimens: A Single Center Retrospective Analysis.Journal of personalized medicine · 2024Article
- Construction of prediction models for determining the risk of lateral lymph node metastasis in patients with thyroid papillary carcinoma based on gender stratification.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2023Article
- Log odds of negative lymph nodes/T stage ratio (LONT): A new prognostic tool for differentiated thyroid cancer without metastases in patients aged 55 and older.Frontiers in endocrinology · 2023Article
- An ultrasound model for predicting recurrence of papillary thyroid carcinoma after complete endoscopic resection.Wideochirurgia i inne techniki maloinwazyjne = Videosurgery and other miniinvasive techniques · 2022Article
- Frozen section analysis of central lymph nodes in papillary thyroid cancer: the significance in determining the extent of surgery.Gland surgery · 2022Article
- Nuances in the Surgical Management of Thyroid Cancer.Indian journal of surgical oncology · 2022Review
- Article
- Reduction of overtreatment without reduction of overdiagnosis in patients with differentiated thyroid cancer: mission impossible.Langenbeck's archives of surgery · 2021Article
- Development and validation of a nomogram based on stromal score to predict progression-free survival of patients with papillary thyroid carcinoma.Cancer medicine · 2021Article
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Authors and funding
12 authors.
Funding
Abstract
backgroundAge 45 years is used as a cutoff in the staging of well-differentiated thyroid cancer (WDTC) as it represents the median age of most datasets. The aim of this study was to determine a statistically optimized age threshold using a large dataset of patients treated at a comprehensive cancer center.
methodsOverall, 1807 patients with a median follow-up of 109 months were included in the study. Recursive partitioning was used to determine which American Joint Committee on Cancer (AJCC) variables were most predictive of disease-specific death, and whether a different cutoff for age would be found. From the resulting tree, a new age cutoff was picked and patients were restaged using this new cutoff.
resultsThe 10-year disease-specific survival (DSS) by Union for International Cancer Control (AJCC/UICC) stage was 99.6, 100, 96, and 81 % for stages I-IV, respectively. Using recursive partitioning, the presence of distant metastasis was the most powerful predictor of DSS. For M0 patients, age was the next most powerful predictor, with a cutoff of 56 years. For M1 patients, a cutoff at 54 years was most predictive. Having reviewed the analysis, age 55 years was selected as a more robust age cutoff than 45 years. The 10-year DSS by new stage (using age 55 years as the cutoff) was 99.2, 98, 100, and 74 % for stages I-IV, respectively.
conclusionA change in age cutoff in the AJCC/UICC staging for WDTC to 55 years would improve the accuracy of the system and appropriately prevent low-risk patients being overstaged and overtreated.
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