ArticleBMC gastroenterology2015
Multicenter study on hemorrhagic risk of heparin bridging therapy for periendoscopic thromboprophylaxis.
Article in BMC gastroenterology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Potential of Direct Oral Anticoagulant in Bleeding After Gastric Endoscopic Submucosal Dissection: A Systematic Review and Meta-Analysis.Digestive diseases and sciences · 2024Pooled it
- Advancements in endoscopic closure: Embracing a new era of managing complications and postprocedural defects after endoscopic submucosal dissection.World journal of gastrointestinal endoscopy · 2025Review
- Article
- Rates and risk factors of bleeding after gastric endoscopic submucosal dissection with continuous warfarin or 1-day withdrawal of direct oral anticoagulants.Journal of gastroenterology and hepatology · 2024Article
- JCS/JHRS 2020 Guideline on Pharmacotherapy of Cardiac Arrhythmias.Journal of arrhythmia · 2022Article
- Recommendation Reversals in Gastroenterology Clinical Practice Guidelines.Journal of the Canadian Association of Gastroenterology · 2022Article
- Article
- Bleeding After Gastric Endoscopic Submucosal Dissection Focused on Management of Xa Inhibitors.Journal of gastric cancer · 2022Article
- Risk of Bleeding after Colorectal Endoscopic Resection in Patients with Continued Warfarin Use Compared to Heparin Replacement: A Propensity Score Matching Analysis.Gastroenterology research and practice · 2021Article
- Platelet Inhibition and Anticoagulation in Visceral Interventions.Visceral medicine · 2020Review
- Use of anticoagulants increases risk of bleeding after colorectal endoscopic submucosal dissection.Endoscopy international open · 2018Article
- A Prospective Multicenter Study Evaluating Bleeding Risk after Endoscopic Ultrasound-Guided Fine Needle Aspiration in Patients Prescribed Antithrombotic Agents.Gut and liver · 2018Article
- Replacement of warfarin with a novel oral anticoagulant in endoscopic mucosal resection: a multicentre, open-label, randomised controlled trial.BMJ open gastroenterology · 2017Article
- A prospective, multicenter survey on the validity of shorter periendoscopic cessation of antithrombotic agents in Japan.Journal of gastroenterology · 2017Observational
- Clinical problems with antithrombotic therapy for endoscopic submucosal dissection for gastric neoplasms.World journal of gastrointestinal endoscopy · 2016Review
Corrections and comments
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Authors and funding
14 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFor endoscopic interventions, heparin bridging therapy is recommended in patients who are at high risk from interruption of antithrombotic therapy. Although heparin bridging has been reported to be effective in preventing thrombosis, several reports have raised concerns about increased risk of bleeding. The aim of this study was to clarify complications of hepari bridging therapy in therapeutic endoscopy.
methodsA nationwide multicenter survey using questionnaire was performed about patients undergoing therapeutic endoscopy with heparin bridging. Patients who underwent therapeutic endoscopy without heparin bridging therapy were considered as controls. Compliance scores of heparin bridging therapy guideline were employed, and association was analyzed between the score and occurrence of post-procedural bleeding.
resultsThe incidence of post-procedural bleeding was significantly higher (13.5%, 33/245) in the heparin group compared with the control group (2.7%, 299/11102)(p < 0.001). Thrombosis occurred in 1 patient each in the two groups. In the heparin group, post-procedural bleeding was more likely to be delayed bleeding. Dose adjustment of heparin was a significant factor contributing to bleeding. The compliance score of heparin bridging therapy guideline was significantly higher in those who suffered bleeding.
conclusionsHeparin bridging therapy significantly increased the risk of post-procedural bleeding compared with the control. The bleeding risk was associated with greater adherence with guidelines for heparin bridging therapy.
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