Evidence map›Paper›PMID 26215052›Full record

Trial reportThe Journal of allergy and clinical immunology2015

Does azithromycin modify viral load during severe respiratory syncytial virus bronchiolitis?

Avraham Beigelman, Leonard B Bacharier, Jack Baty, Richard Buller, Sheila Mason, Kenneth B Schechtman, Geneline Sajol, Megan Isaacson-Schmid, Mario Castro, Gregory A Storch

Registry-linked trialAbstract readLetterMulticenter StudyRandomized Controlled Trial
In one paragraph

Trial report in The Journal of allergy and clinical immunology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04353271 (A Randomized Phase 2/3 Trial of Hydroxychloroquine In Covid-19 Kinetics), which is not on this map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04353271 phase2 / phase3terminatednot on this mapstarted 2020, after this paper: background citation

A Randomized Phase 2/3 Trial of Hydroxychloroquine In Covid-19 Kinetics

TypeinterventionalSponsorUniversity of South AlabamaRan2020 to 2020Enrolled3ConditionsCovid 19, Corona Virus InfectionArmsHydroxychloroquine, Placebo
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Observational
  4. Macrolides in critically ill patients with Middle East Respiratory Syndrome.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2019
    Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Avraham BeigelmanDepartment of Pediatrics, Washington University School of Medicine and St Louis Children's Hospital, St Louis, Mo. Electronic address: beigelman_a@kids.wustl.edu.
Leonard B BacharierDepartment of Pediatrics, Washington University School of Medicine and St Louis Children's Hospital, St Louis, Mo.
Jack BatyDivision of Biostatistics, Washington University School of Medicine and St Louis Children's Hospital, St Louis, Mo.
Richard BullerDepartment of Pediatrics, Washington University School of Medicine and St Louis Children's Hospital, St Louis, Mo.
Sheila MasonDepartment of Pediatrics, Washington University School of Medicine and St Louis Children's Hospital, St Louis, Mo.
Kenneth B SchechtmanDivision of Biostatistics, Washington University School of Medicine and St Louis Children's Hospital, St Louis, Mo.
Geneline SajolDepartment of Internal Medicine, Washington University School of Medicine and St Louis Children's Hospital, St Louis, Mo.
Megan Isaacson-SchmidDepartment of Pediatrics, Washington University School of Medicine and St Louis Children's Hospital, St Louis, Mo.
Mario CastroDepartment of Internal Medicine, Washington University School of Medicine and St Louis Children's Hospital, St Louis, Mo.
Gregory A StorchDepartment of Pediatrics, Washington University School of Medicine and St Louis Children's Hospital, St Louis, Mo.

Funding

Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI TIMOTHY J. EBERLEIN · 2001 to 2026
$128.0M
Washington University Institute of Clinical and Translational SciencesUL1TR000448 · NCATS · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2012 to 2016
$41.4M
Washington University Institute of Clinical and Translational SciencesKL2TR000450 · NCATS · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2012 to 2016
$8.8M
DEFINING THE HUMAN VIROME IN IMMUNOCOMPROMISED CHILDRENR01AI097213 · NIAID · WASHINGTON UNIVERSITY · PI STORCH, GREGORY A. · 2012 to 2016
$3.2M
NCATS NIH HHS KL2 TR000450NCATS NIH HHS UL1 TR000448NCI NIH HHS P30 CA091842NIAID NIH HHS R01 AI097213
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Bronchiolitis, ViralRespiratory Syncytial VirusesRespiratory Syncytial Virus InfectionsViral LoadAnti-Bacterial AgentsAzithromycinFemaleHumansInfantInfant, NewbornMaleAnti-Bacterial AgentsAzithromycin

Identifiers

PMID26215052
PMCPMC4600448

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.