Trial reportPloS one2015
Automated Peritoneal Dialysis Is Associated with Better Survival Rates Compared to Continuous Ambulatory Peritoneal Dialysis: A Propensity Score Matching Analysis.
Trial report in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT05449067 (Nocturnal Automated Versus Continuous Ambulatory Peritoneal Dialysis in Patients With End-Stage Kidney Disease), which is not on this map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Nocturnal Automated Versus Continuous Ambulatory Peritoneal Dialysis in Patients With End-Stage Kidney Disease: A Multicenter, Randomized, Open-Label, Crossover Non-Inferiority Trial
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Automated peritoneal dialysis versus continuous ambulatory peritoneal dialysis for people with kidney failure.The Cochrane database of systematic reviews · 2024Pooled it
- Safety, Effectiveness, and Manipulability of Peritoneal Dialysis Machines Made in China: A Randomized, Crossover, Multicenter Clinical Study.Chinese medical journal · 2018Trial
- Comparison of clinical outcomes based on dialysis modality and icodextrin usage in patients on peritoneal dialysis.Kidney research and clinical practice · 2026Article
- Blood Pressure Level and Risk of All-Cause Mortality in Patients With Kidney Failure on Maintenance Peritoneal Dialysis: A Systematic Review and Meta-Analysis of Observational Studies.Kidney medicine · 2026Article
- Risk of first peritonitis episode in continuous ambulatory peritoneal dialysis and automated peritoneal dialysis: a population-based study.Clinical kidney journal · 2024Article
- Impact of peritoneal dialysis strategy on technique and patient survival.Clinical kidney journal · 2023Article
- Article
- Similar survival on home haemodialysis and automated peritoneal dialysis: an inception cohort study.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2022Article
- APD or CAPD: one glove does not fit all.International urology and nephrology · 2021Review
- Automated Peritoneal Dialysis: Patient Perspectives and Outcomes.International journal of nephrology and renovascular disease · 2021Review
- Comparison of sodium removal in peritoneal dialysis patients treated by continuous ambulatory and automated peritoneal dialysis.Journal of nephrology · 2019Article
- Racial and social disparities in the access to automated peritoneal dialysis - results of a national PD cohort.Scientific reports · 2017Article
- Do Automated Peritoneal Dialysis and Continuous Ambulatory Peritoneal Dialysis Have the Same Clinical Outcomes? A Ten-year Cohort Study in Taiwan.Scientific reports · 2016Article
- Article
Corrections and comments
- Erratum issued
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe impact of peritoneal dialysis modality on patient survival and peritonitis rates is not fully understood, and no large-scale randomized clinical trial (RCT) is available. In the absence of a RCT, the use of an advanced matching procedure to reduce selection bias in large cohort studies may be the best approach. The aim of this study is to compare automated peritoneal dialysis (APD) and continuous ambulatory peritoneal dialysis (CAPD) according to peritonitis risk, technique failure and patient survival in a large nation-wide PD cohort.
methodsThis is a prospective cohort study that included all incident PD patients with at least 90 days of PD recruited in the BRAZPD study. All patients who were treated exclusively with either APD or CAPD were matched for 15 different covariates using a propensity score calculated with the nearest neighbor method. Clinical outcomes analyzed were overall mortality, technique failure and time to first peritonitis. For all analysis we also adjusted the curves for the presence of competing risks with the Fine and Gray analysis.
resultsAfter the matching procedure, 2,890 patients were included in the analysis (1,445 in each group). Baseline characteristics were similar for all covariates including: age, diabetes, BMI, Center-experience, coronary artery disease, cancer, literacy, hypertension, race, previous HD, gender, pre-dialysis care, family income, peripheral artery disease and year of starting PD. Mortality rate was higher in CAPD patients (SHR1.44 CI95%1.21-1.71) compared to APD, but no difference was observed for technique failure (SHR0.83 CI95%0.69-1.02) nor for time till the first peritonitis episode (SHR0.96 CI95%0.93-1.11).
conclusionIn the first large PD cohort study with groups balanced for several covariates using propensity score matching, PD modality was not associated with differences in neither time to first peritonitis nor in technique failure. Nevertheless, patient survival was significantly better in APD patients.
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