ArticleNature genetics2015
Analysis of mammalian gene function through broad-based phenotypic screens across a consortium of mouse clinics.
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Article in Nature genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 99 papers, 1 of them a synthesis that pooled it.
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99citing papers in PubMed, 1 pooled it
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Who cites it
99 citing papers in PubMed, 1 synthesis or guideline pooled it.
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- Most Pleiotropic Effects of Gene Knockouts Are Evolutionarily Transient in Yeasts.Molecular biology and evolution · 2024Article
- Pleiotropy, epistasis and the genetic architecture of quantitative traits.Nature reviews. Genetics · 2024Review
- Essential role of p21Stem cell research & therapy · 2024Article
- The GPI-anchor biosynthesis pathway is critical for syncytiotrophoblast differentiation and placental development.Cellular and molecular life sciences : CMLS · 2024Article
- Single-cell and bulk transcriptional profiling of mouse ovaries reveals novel genes and pathways associated with DNA damage response in oocytes.bioRxiv : the preprint server for biology · 2024Article
- Addressing pitfalls in translation.Neuroscience applied · 2024Article
- A consensus score to combine inferences from multiple centres.Mammalian genome : official journal of the International Mammalian Genome Society · 2023Article
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- Knockout mice are an important tool for human monogenic heart disease studies.Disease models & mechanisms · 2023Article
- A multi-lab experimental assessment reveals that replicability can be improved by using empirical estimates of genotype-by-lab interaction.PLoS biology · 2023Article
- Comparative landscape of genetic dependencies in human and chimpanzee stem cells.bioRxiv : the preprint server for biology · 2023Article
- The Effect of Developmental Pleiotropy on the Evolution of Insect Immune Genes.Genome biology and evolution · 2023Article
- Defects in placental syncytiotrophoblast cells are a common cause of developmental heart disease.Nature communications · 2023Article
- The International Mouse Phenotyping Consortium: comprehensive knockout phenotyping underpinning the study of human disease.Nucleic acids research · 2023Article
- Multivariate phenotype analysis enables genome-wide inference of mammalian gene function.PLoS biology · 2022Article
39 more citing papers are in PubMed but not listed here.
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Authors and funding
169 authors.
Martin Hrabě de Angelis *German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.
George Nicholson *Department of Statistics, University of Oxford, Oxford, UK.
Mohammed Selloum *Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.
Jacqui White *The Wellcome Trust Sanger Institute, Hinxton, UK.
Hugh Morgan *MRC Harwell, Medical Research Council, Harwell, UK.
Ramiro Ramirez-Solis *The Wellcome Trust Sanger Institute, Hinxton, UK.
Tania Sorg *Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.
Sara Wells *MRC Harwell, Medical Research Council, Harwell, UK.
Helmut Fuchs *German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.
Martin Fray *MRC Harwell, Medical Research Council, Harwell, UK.
David J AdamsThe Wellcome Trust Sanger Institute, Hinxton, UK.
Niels C AdamsThe Wellcome Trust Sanger Institute, Hinxton, UK.
Thure AdlerGerman Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.
Antonio Aguilar-PimentelGerman Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.
Dalila Ali-HadjiInstitut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.
Gregory AmannInstitut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.
Philippe AndréInstitut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.
Sarah AtkinsMRC Harwell, Medical Research Council, Harwell, UK.
Aurelie AuburtinInstitut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.
Abdel AyadiInstitut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.
Julien BeckerInstitut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.
Lore BeckerGerman Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.
Elodie BeduInstitut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.
Raffi BekeredjianGerman Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.
Marie-Christine BirlingInstitut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.
Andrew BlakeMRC Harwell, Medical Research Council, Harwell, UK.
Joanna BottomleyThe Wellcome Trust Sanger Institute, Hinxton, UK.
Mike BowlMRC Harwell, Medical Research Council, Harwell, UK.
Véronique BraultInstitut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France.
Dirk H BuschInstitute for Medical Microbiology, Immunology and Hygiene, Technische Universität München, Munich, Germany.
James N BussellThe Wellcome Trust Sanger Institute, Hinxton, UK.
Julia Calzada-WackInstitute of Pathology, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.
Heather CaterMRC Harwell, Medical Research Council, Harwell, UK.
Marie-France ChampyInstitut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.
Philippe CharlesInstitut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.
Claire ChevalierInstitut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France.
Francesco ChianiInstitute of Cell Biology and Neurology, CNR (National Research Council), Rome, Italy.
Gemma F CodnerMRC Harwell, Medical Research Council, Harwell, UK.
Roy CombeInstitut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.
Roger CoxMRC Harwell, Medical Research Council, Harwell, UK.
Emilie DalloneauInstitut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France.
André DierichInstitut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.
Armida Di FenzaMRC Harwell, Medical Research Council, Harwell, UK.
Brendan DoeInstitute of Cell Biology and Neurology, CNR (National Research Council), Rome, Italy.
Arnaud DuchonInstitut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France.
Oliver EickelbergInstitute of Lung Biology and Disease, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.
Chris T EsapaMRC Harwell, Medical Research Council, Harwell, UK.
Lahcen El FertakInstitut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.
Tanja FeigelMRC Harwell, Medical Research Council, Harwell, UK.
Irina EmelyanovaMRC Harwell, Medical Research Council, Harwell, UK.
Jeanne EstabelThe Wellcome Trust Sanger Institute, Hinxton, UK.
Jack FavorInstitute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.
Ann FlennikenLunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Canada.
Alessia GambadoroInstitute of Cell Biology and Neurology, CNR (National Research Council), Rome, Italy.
Lilian GarrettInstitute of Developmental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.
Hilary GatesMRC Harwell, Medical Research Council, Harwell, UK.
Anna-Karin GerdinThe Wellcome Trust Sanger Institute, Hinxton, UK.
George GkoutosDepartment of Computer Science, University of Aberystwyth, UK.
Simon GreenawayMRC Harwell, Medical Research Council, Harwell, UK.
Lisa GlaslInstitute of Developmental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.
Patrice GoetzInstitut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.
Isabelle Goncalves Da CruzInstitut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.
Alexander GötzInstitute of Lung Biology and Disease, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.
Jochen GrawInstitute of Developmental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.
Alain GuimondInstitut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.
Wolfgang HansGerman Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.
Geoff HicksManitoba Institute of Cell Biology, University of Manitoba, Winnipeg, Canada.
Sabine M HölterInstitute of Developmental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.
Heinz HöflerDeptartment of Neurology, Klinikum der Ludwig-Maximilians-Universität München, Germany.
John M HancockMRC Harwell, Medical Research Council, Harwell, UK.
Robert HoehndorfComputational Bioscience Research Center, King Abdullah University of Science and Technology, Kingdom of Saudi Arabia.
Tertius HoughMRC Harwell, Medical Research Council, Harwell, UK.
Richard HoughtonThe Wellcome Trust Sanger Institute, Hinxton, UK.
Anja HurtGerman Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.
Boris IvandicGerman Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.
Hughes JacobsInstitut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.
Sylvie JacquotInstitut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.
Nora JonesLunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Canada.
Natasha A KarpThe Wellcome Trust Sanger Institute, Hinxton, UK.
Hugo A KatusGerman Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.
Sharon KitchenMRC Harwell, Medical Research Council, Harwell, UK.
Tanja Klein-RodewaldInstitute of Pathology, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.
Martin KlingensporGerman Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.
Thomas KlopstockGerman Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.
Valerie LalanneInstitut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.
Sophie LeblancInstitut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.
Christoph LenggerGerman Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.
Elise le MarchandInstitut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.
Tonia LudwigGerman Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.
Aline LuxInstitut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.
Colin McKerlieToronto Centre for Phenogenomics, Toronto, Canada.
Holger MaierGerman Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.
Jean-Louis MandelInstitut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.
Susan MarschallGerman Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.
Manuel MarkInstitut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.
David G MelvinThe Wellcome Trust Sanger Institute, Hinxton, UK.
Hamid MezianeInstitut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.
Kateryna MicklichGerman Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.
Christophe MittelhauserInstitut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.
Laurent MonassierInstitut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.
David MoulaertInstitut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.
Stéphanie MullerInstitut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.
Beatrix NatonGerman Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.
Frauke NeffInstitute of Pathology, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.
Patrick M NolanMRC Harwell, Medical Research Council, Harwell, UK.
Lauryl Mj NutterThe Hospital for Sick Children, Toronto, Canada.
Markus OllertGerman Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.
Guillaume PavlovicInstitut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.
Natalia S PellegataInstitute of Pathology, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.
Emilie PeterInstitut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.
Benoit Petit-DemoulièreInstitut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.
Amanda PickardMRC Harwell, Medical Research Council, Harwell, UK.
Christine PodriniThe Wellcome Trust Sanger Institute, Hinxton, UK.
Paul PotterMRC Harwell, Medical Research Council, Harwell, UK.
Laurent PouillyInstitut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.
Oliver PukInstitute of Developmental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.
David RichardsonThe Wellcome Trust Sanger Institute, Hinxton, UK.
Stephane RousseauInstitut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.
Leticia Quintanilla-FendInstitute of Pathology, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.
Mohamed M QuwailidMRC Harwell, Medical Research Council, Harwell, UK.
Ildiko RaczGerman Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.
Birgit RathkolbGerman Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.
Fabrice RietInstitut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.
Janet RossantThe Hospital for Sick Children, Toronto, Canada.
Michel RouxInstitut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.
Jan RozmanGerman Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.
Ed RyderThe Wellcome Trust Sanger Institute, Hinxton, UK.
Jennifer SalisburyThe Wellcome Trust Sanger Institute, Hinxton, UK.
Luis SantosMRC Harwell, Medical Research Council, Harwell, UK.
Karl-Heinz SchäbleGerman Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.
Evelyn SchillerGerman Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.
Anja SchreweGerman Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.
Holger SchulzInstitute of Lung Biology and Disease, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.
Ralf SteinkampGerman Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.
Michelle SimonMRC Harwell, Medical Research Council, Harwell, UK.
Michelle StewartMRC Harwell, Medical Research Council, Harwell, UK.
Claudia StögerGerman Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.
Tobias StögerInstitute of Lung Biology and Disease, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.
Minxuan SunInstitute of Developmental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.
David SunterThe Wellcome Trust Sanger Institute, Hinxton, UK.
Lydia TeboulMRC Harwell, Medical Research Council, Harwell, UK.
Isabelle TillyInstitut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.
Glauco P Tocchini-ValentiniInstitute of Cell Biology and Neurology, CNR (National Research Council), Rome, Italy.
Monica TostInstitute of Pathology, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.
Irina TreiseGerman Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.
Laurent VasseurInstitut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.
Emilie VelotInstitut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France.
Daniela Vogt-WeisenhornInstitute of Developmental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.
Christelle WagnerInstitut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.
Alison WallingMRC Harwell, Medical Research Council, Harwell, UK.
Bruno WeberInstitut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.
Olivia WendlingInstitut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.
Henrik WesterbergMRC Harwell, Medical Research Council, Harwell, UK.
Monja WillershäuserGerman Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.
Eckhard WolfInstitute of Molecular Animal Breeding and Biotechnology, Ludwigs-Maximilians-University Munich, Munich, Germany.
Anne WolterInstitut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.
Joe WoodMRC Harwell, Medical Research Council, Harwell, UK.
Wolfgang WurstInstitute of Developmental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.
Ali Önder YildirimInstitute of Lung Biology and Disease, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.
Ramona ZehGerman Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.
Andreas ZimmerGerman Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.
Annemarie ZimprichInstitute of Developmental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.
EUMODIC Consortium
Chris Holmes *Department of Statistics, University of Oxford, Oxford, UK.
Karen P Steel *The Wellcome Trust Sanger Institute, Hinxton, UK.
Yann Herault *Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.
Valérie Gailus-Durner *German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.
Ann-Marie Mallon *MRC Harwell, Medical Research Council, Harwell, UK.
Steve Dm Brown *MRC Harwell, Medical Research Council, Harwell, UK.
Funding
Cancer Research UK 13031Medical Research Council G0300212Medical Research Council MC_QA137918Medical Research Council MC_U142661184Medical Research Council MC_U142684171Medical Research Council MC_U142684172Medical Research Council MC_U142684175Medical Research Council MC_UP_1502/3Wellcome Trust 084655
Abstract
The function of the majority of genes in the mouse and human genomes remains unknown. The mouse embryonic stem cell knockout resource provides a basis for the characterization of relationships between genes and phenotypes. The EUMODIC consortium developed and validated robust methodologies for the broad-based phenotyping of knockouts through a pipeline comprising 20 disease-oriented platforms. We developed new statistical methods for pipeline design and data analysis aimed at detecting reproducible phenotypes with high power. We acquired phenotype data from 449 mutant alleles, representing 320 unique genes, of which half had no previous functional annotation. We captured data from over 27,000 mice, finding that 83% of the mutant lines are phenodeviant, with 65% demonstrating pleiotropy. Surprisingly, we found significant differences in phenotype annotation according to zygosity. New phenotypes were uncovered for many genes with previously unknown function, providing a powerful basis for hypothesis generation and further investigation in diverse systems.
Indexed as
Genetic Association StudiesAnimalsFemaleHeterozygoteHomozygoteHumansMaleMice, Inbred C57BLMice, KnockoutMolecular Sequence AnnotationMutationPhenotype
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