Evidence map›Paper›PMID 26214361›Full record

ArticleSocial neuroscience2016

Structural integrity of the limbic-prefrontal connection: Neuropathological correlates of anxiety in Williams syndrome.

Rowena Ng, Timothy T Brown, Anna M Järvinen, Matthew Erhart, Julie R Korenberg, Ursula Bellugi, Eric Halgren

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Social neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Rowena Nga Laboratory for Cognitive Neuroscience , Salk Institute for Biological Studies , La Jolla , CA , USA.
Timothy T Brownc Multimodal Imaging Laboratory , University of California San Diego , La Jolla , CA , USA.
Anna M Järvinena Laboratory for Cognitive Neuroscience , Salk Institute for Biological Studies , La Jolla , CA , USA.
Matthew Erhartc Multimodal Imaging Laboratory , University of California San Diego , La Jolla , CA , USA.
Julie R Korenberge Center for Integrated Neuroscience and Human Behavior , University of Utah , Salt Lake City , UT , USA.
Ursula Bellugia Laboratory for Cognitive Neuroscience , Salk Institute for Biological Studies , La Jolla , CA , USA.
Eric Halgrenc Multimodal Imaging Laboratory , University of California San Diego , La Jolla , CA , USA.

Funding

Williams Syndrome: The Molecular Genetic CharacterizationP01HD033113 · NICHD · UNIVERSITY OF UTAH · PI HALGREN, ERIC · 1996 to 2015
$19.4M
VARIANTS OF FOCAL BRAIN INJURYP50NS022343 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CEPONIENE, RITA · 1985 to 2012
$15.1M
NICHD NIH HHS P01 HD033113NINDS NIH HHS P50 NS022343PHS HHS 033113PHS HHS 22343
6 · The paper itself

Abstract

Williams syndrome (WS) is a genetic condition characterized by a hypersocial personality and desire to form close relationships, juxtaposed with significant anxieties of nonsocial events. The neural underpinnings of anxiety in individuals with WS are currently unknown. Aberrations in the anatomical and microstructural integrity of the uncinate fasciculus (UF) have been recently implicated in social and generalized anxiety disorders. Based on these findings, we tested the hypothesis that the reported anxieties in individuals with WS share similar neuropathological correlates. Toward this end, diffusion tensor imaging (DTI) methods were employed to examine the microstructural integrity (fractional anisotropy, mean diffusivity, longitudinal diffusivity) of the UF in 18 WS and 15 typically developing adults (TD). Anxiety and sociability questionnaires were administered to determine associations with DTI indices of UF across groups. Results revealed comparable white matter integrity of the UF across groups, yet elevated subjective experience of anxiety in those with WS. Additionally, sociability and UF microstructural properties were dissociated across both groups. Whereas no relationships were found between DTI indices and anxiety in TD participants, strong negative associations were observed between these constructs in individuals with WS. Findings indicated that increased anxiety manifested by individuals with WS was associated with DTI measures of the UF and may signal structural or possibly physiological aberration involving this tract within the prefrontal-temporal network.

Indexed as

AdolescentAdultAnalysis of VarianceAnxietyCognition DisordersDiffusion Magnetic Resonance ImagingFemaleHumansImage Processing, Computer-AssistedLimbic SystemMaleMiddle AgedNeural PathwaysNeuropsychological TestsPrefrontal CortexSurveys and QuestionnairesAnxietyDTISociabilityUncinate fasciculusWilliams syndrome

Identifiers

PMID26214361
PMCPMC4729666

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.