ArticleBehavioral neuroscience2015
Oxytocin reduces amygdala activity, increases social interactions, and reduces anxiety-like behavior irrespective of NMDAR antagonism.
Article in Behavioral neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Exploring the efficacy of intranasal oxytocin (OXT) for anxiety and stress-related disorders through functional magnetic resonance imaging (fMRI) study: a systematic review.BMC pharmacology & toxicology · 2025Pooled it
- Music's context-dependent influence on oxytocin, social bonding, and emotion regulation: a systematic review.Frontiers in cognition · 2025Pooled it
- The Amygdala and Politics.Brain sciences · 2026Review
- Oxytocin selectively biases sensory-prefrontal communication through network-level suppression and theta coupling.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- The Occipital-Fronto-Limbic Circuit of Body Dysmorphic Disorder: A Systematic Review and Meta-Analysis of Neuroimaging Studies.Biological psychiatry global open science · 2026Article
- Oxytocin in the Amygdala Sustains Prosocial Behavior via State-Dependent Amygdala-Prefrontal Modulation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Oxytocin, Vasopressin and Stress: A Hormetic Perspective.Current issues in molecular biology · 2025Review
- Neuropeptide receptor distributions in male and femaleBiology letters · 2025Article
- Transcriptome analysis identifies an ASD-Like phenotype in oligodendrocytes and microglia from C58/J amygdala that is dependent on sex and sociability.Behavioral and brain functions : BBF · 2024Article
- Antipsychotic effect of diosgenin in ketamine-induced murine model of schizophrenia: Involvement of oxidative stress and cholinergic transmission.IBRO neuroscience reports · 2024Article
- Exploring the influence of stress on aggressive behavior and sexual function: Role of neuromodulator pathways and epigenetics.Heliyon · 2024Review
- Oxytocin Enhances Time-Dependent Responses in the Aggressive Zebrafish (Brain sciences · 2024Article
- Paraventricular oxytocin neurons impact energy intake and expenditure: projections to the bed nucleus of the stria terminalis reduce sucrose consumption.Frontiers in endocrinology · 2024Article
- Neurobiological traces of grief: Examining the impact of offspring loss after birth on rat mothers' brain and stress-coping behavior in the first week postpartum.Neuroscience applied · 2024Article
- The Relevance of Animal Models of Social Isolation and Social Motivation for Understanding Schizophrenia: Review and Future Directions.Schizophrenia bulletin · 2023Review
- Examining associations between MDMA/ecstasy and classic psychedelic use and impairments in social functioning in a U.S. adult sample.Scientific reports · 2023Article
- Oxytocin enhances basolateral amygdala activation and functional connectivity while processing emotional faces: preliminary findings in autistic vs non-autistic women.Social cognitive and affective neuroscience · 2022Article
- Intraamygdaloid Oxytocin Reduces Anxiety in the Valproate-Induced Autism Rat Model.Biomedicines · 2022Article
- The modulation of emotional and social behaviors by oxytocin signaling in limbic network.Frontiers in molecular neuroscience · 2022Review
- Oxytocin-induced anxiogenic behavior in juvenile male rats.Animal cells and systems · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Standard dopamine therapies for schizophrenia are not efficacious for negative symptoms of the disease, including asociality. This reduced social behavior may be due to glutamatergic dysfunction within the amygdala, leading to increased fear and social anxiety. Several studies have demonstrated the prosocial effects of oxytocin in schizophrenia patients. Therefore, this study evaluates the effect of subchronic oxytocin on EEG activity in amygdala of mice during performance of the three-chamber social choice and open field tests following acute ketamine as a model of glutamatergic dysfunction. Oxytocin did not restore social deficits introduced by ketamine but did significantly increase sociality in comparison to the control group. Ketamine had no effect on time spent in the center during the open field trials, whereas oxytocin increased overall center time across all groups, suggesting a reduction in anxiety. Amygdala activity was consistent across all drug groups during social and nonsocial behavioral trials. However, oxytocin reduced overall amygdala EEG power during the two behavioral tasks. Alternatively, ketamine did not significantly affect EEG power throughout the tasks. Decreased EEG power in the amygdala, as caused by oxytocin, may be related to both reduced anxiety and increased social behaviors. Data suggest that separate prosocial and social anxiety pathways may mediate social preference.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.