ArticleEndocrinology2015
Coenzyme Q10 Prevents Insulin Signaling Dysregulation and Inflammation Prior to Development of Insulin Resistance in Male Offspring of a Rat Model of Poor Maternal Nutrition and Accelerated Postnatal Growth.
Article in Endocrinology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 33 citations in OpenAlex.
- Review: The Protective Impact of Supplementation and Exercise against Maternal Malnutrition: Environment as a Key Determinant of Health or Disease.Cell biochemistry and biophysics · 2026Review
- Coenzyme Q10 protects keratinocytes against oxidation-induced energy stress as revealed by spatiotemporal analysis of cell energetics.Scientific reports · 2025Article
- Effects of coenzyme q10 supplementation on metabolic and reproductive outcomes in obese rats.Journal of ovarian research · 2025Article
- Maternal Protein Restriction in Rats Alters Postnatal Growth and Brain Lipid Sensing in Female Offspring.Nutrients · 2023Article
- Effects of coenzyme Q10 supplementation on glycemic control: A GRADE-assessed systematic review and dose-response meta-analysis of randomized controlled trials.EClinicalMedicine · 2022Article
- Impact of Metformin Treatment on Human Placental Energy Production and Oxidative Stress.Frontiers in cell and developmental biology · 2022Article
- Role of Coenzyme QAntioxidants (Basel, Switzerland) · 2021Review
- Quantification of fetal organ sparing in maternal low-protein dietary models.Wellcome open research · 2021Article
- Strength of nonhuman primate studies of developmental programming: review of sample sizes, challenges, and steps for future work.Journal of developmental origins of health and disease · 2020Review
- Effect of maternal baboon (Papio sp.) dietary mismatch in pregnancy and lactation on post-natal offspring early life phenotype.Journal of medical primatology · 2019Article
- Chronic gestational hypoxia accelerates ovarian aging and lowers ovarian reserve in next-generation adult rats.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Chronic fetal hypoxia disrupts the peri-conceptual environment in next-generation adult female rats.The Journal of physiology · 2019Article
- Effect of Coenzyme QBiomolecules · 2018Review
- Insulin-signalling dysregulation and inflammation is programmed trans-generationally in a female rat model of poor maternal nutrition.Scientific reports · 2018Article
- Early nutrition and ageing: can we intervene?Biogerontology · 2017Review
- Radish (Raphanus sativus) and Diabetes.Nutrients · 2017Review
- Cell-autonomous programming of rat adipose tissue insulin signalling proteins by maternal nutrition.Diabetologia · 2016Article
Corrections and comments
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Authors and funding
8 authors at 6 institutions in 1 country.
Funding
Abstract
Low birth weight and rapid postnatal growth increases the risk of developing insulin resistance and type 2 diabetes in later life. However, underlying mechanisms and potential intervention strategies are poorly defined. Here we demonstrate that male Wistar rats exposed to a low-protein diet in utero that had a low birth weight but then underwent postnatal catch-up growth (recuperated offspring) had reductions in the insulin signaling proteins p110-β (13% ± 6% of controls [P < .001]) and insulin receptor substrate-1 (39% ± 10% of controls [P < .05]) in adipose tissue. These changes were not accompanied by any change in expression of the corresponding mRNAs, suggesting posttranscriptional regulation. Recuperated animals displayed evidence of a proinflammatory phenotype of their adipose tissue with increased IL-6 (139% ± 8% [P < .05]) and IL1-β (154% ± 16% [P < .05]) that may contribute to the insulin signaling protein dysregulation. Postweaning dietary supplementation of recuperated animals with coenzyme Q (CoQ10) (1 mg/kg of body weight per day) prevented the programmed reduction in insulin receptor substrate-1 and p110-β and the programmed increased in IL-6. These findings suggest that postweaning CoQ10 supplementation has antiinflammatory properties and can prevent programmed changes in insulin-signaling protein expression. We conclude that CoQ10 supplementation represents an attractive intervention strategy to prevent the development of insulin resistance that results from suboptimal in utero nutrition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.