ArticleEndocrinology2015
Thyroid Hormone Signaling in Male Mouse Skeletal Muscle Is Largely Independent of D2 in Myocytes.
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Article in Endocrinology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
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Who cites it
18 citing papers in PubMed, 25 citations in OpenAlex.
- Measuring deiodinase activity: a need for standardization?European thyroid journal · 2026Article
- Causal associations between thyroid function and sarcopenia-related traits: a Mendelian randomization study.Hormones (Athens, Greece) · 2025Article
- Thr92Ala-DIO2 heterozygosity is associated with skeletal muscle mass and myosteatosis in patients with COVID-19.European thyroid journal · 2024Article
- The role of transducin β-like 1 X-linked receptor 1 (TBL1XR1) in thyroid hormone metabolism and action in mice.European thyroid journal · 2023Article
- Thyroid Hormone Regulates the Lipid Content of Muscle Fibers, Thus Affecting Physical Exercise Performance.International journal of molecular sciences · 2023Article
- Selenium Status and Its Antioxidant Role in Metabolic Diseases.Oxidative medicine and cellular longevity · 2022Review
- Deiodinases and the Metabolic Code for Thyroid Hormone Action.Endocrinology · 2021Review
- Central vs. Peripheral Action of Thyroid Hormone in Adaptive Thermogenesis: A Burning Topic.Cells · 2021Review
- A Type 2 Deiodinase-Dependent Increase inThyroid : official journal of the American Thyroid Association · 2021Article
- Deiodinases and their intricate role in thyroid hormone homeostasis.Nature reviews. Endocrinology · 2019Review
- Paradigms of Dynamic Control of Thyroid Hormone Signaling.Endocrine reviews · 2019Review
- A Global Loss of Dio2 Leads to Unexpected Changes in Function and Fiber Types of Slow Skeletal Muscle in Male Mice.Endocrinology · 2019Article
- Early Developmental Disruption of Type 2 Deiodinase Pathway in Mouse Skeletal Muscle Does Not Impair Muscle Function.Thyroid : official journal of the American Thyroid Association · 2017Article
- Variable Cold-Induced Brown Adipose Tissue Response to Thyroid Hormone Status.Thyroid : official journal of the American Thyroid Association · 2017Article
- Thyroid hormone activation by type 2 deiodinase mediates exercise-induced peroxisome proliferator-activated receptor-γ coactivator-1α expression in skeletal muscle.The Journal of physiology · 2016Article
- Type 2 Deiodinase Disruption in Astrocytes Results in Anxiety-Depressive-Like Behavior in Male Mice.Endocrinology · 2016Article
- Thyroid Hormone Receptor α Plays an Essential Role in Male Skeletal Muscle Myoblast Proliferation, Differentiation, and Response to Injury.Endocrinology · 2016Article
- Coupling between Nutrient Availability and Thyroid Hormone Activation.The Journal of biological chemistry · 2015Article
Corrections and comments
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Authors and funding
10 authors at 6 institutions in 3 countries.
Joao P Werneck-de-CastroDivision of Endocrinology and Metabolism (J.P.W.d.C., T.L.F., G.W.F., A.C.B.), Rush University Medical Center, Chicago Illinois 60612; Division of Endocrinology, Diabetes, and Metabolism (J.P.W.d.C., D.L.I., C.M.A.F., L.J.L., M.B.R.), University of Miami Miller School of Medicine, Miami, Florida 33101-6960; Biophysics Institute and School of Physical Education and Sports (J.P.W.d.C., D.L.I., M.B.R.), Federal University of Rio de Janeiro, 21941-901 Rio de Janeiro, Brazil; Developmental Disorders Program (M.O.R.), Center for Biological and Health Sciences, Mackenzie Presbyterian University, 01302 Sao Paulo, Brazil; Department of Endocrine Neurobiology (B.G.), Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, H-1083 Hungary; and Translational Medicine (G.W.F.), Federal University of Sao Paulo, 01302-907 Sao Paulo, Brazil.
Tatiana L FonsecaDivision of Endocrinology and Metabolism (J.P.W.d.C., T.L.F., G.W.F., A.C.B.), Rush University Medical Center, Chicago Illinois 60612; Division of Endocrinology, Diabetes, and Metabolism (J.P.W.d.C., D.L.I., C.M.A.F., L.J.L., M.B.R.), University of Miami Miller School of Medicine, Miami, Florida 33101-6960; Biophysics Institute and School of Physical Education and Sports (J.P.W.d.C., D.L.I., M.B.R.), Federal University of Rio de Janeiro, 21941-901 Rio de Janeiro, Brazil; Developmental Disorders Program (M.O.R.), Center for Biological and Health Sciences, Mackenzie Presbyterian University, 01302 Sao Paulo, Brazil; Department of Endocrine Neurobiology (B.G.), Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, H-1083 Hungary; and Translational Medicine (G.W.F.), Federal University of Sao Paulo, 01302-907 Sao Paulo, Brazil.
Daniele L IgnacioDivision of Endocrinology and Metabolism (J.P.W.d.C., T.L.F., G.W.F., A.C.B.), Rush University Medical Center, Chicago Illinois 60612; Division of Endocrinology, Diabetes, and Metabolism (J.P.W.d.C., D.L.I., C.M.A.F., L.J.L., M.B.R.), University of Miami Miller School of Medicine, Miami, Florida 33101-6960; Biophysics Institute and School of Physical Education and Sports (J.P.W.d.C., D.L.I., M.B.R.), Federal University of Rio de Janeiro, 21941-901 Rio de Janeiro, Brazil; Developmental Disorders Program (M.O.R.), Center for Biological and Health Sciences, Mackenzie Presbyterian University, 01302 Sao Paulo, Brazil; Department of Endocrine Neurobiology (B.G.), Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, H-1083 Hungary; and Translational Medicine (G.W.F.), Federal University of Sao Paulo, 01302-907 Sao Paulo, Brazil.
Gustavo W FernandesDivision of Endocrinology and Metabolism (J.P.W.d.C., T.L.F., G.W.F., A.C.B.), Rush University Medical Center, Chicago Illinois 60612; Division of Endocrinology, Diabetes, and Metabolism (J.P.W.d.C., D.L.I., C.M.A.F., L.J.L., M.B.R.), University of Miami Miller School of Medicine, Miami, Florida 33101-6960; Biophysics Institute and School of Physical Education and Sports (J.P.W.d.C., D.L.I., M.B.R.), Federal University of Rio de Janeiro, 21941-901 Rio de Janeiro, Brazil; Developmental Disorders Program (M.O.R.), Center for Biological and Health Sciences, Mackenzie Presbyterian University, 01302 Sao Paulo, Brazil; Department of Endocrine Neurobiology (B.G.), Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, H-1083 Hungary; and Translational Medicine (G.W.F.), Federal University of Sao Paulo, 01302-907 Sao Paulo, Brazil.
Cristina M Andrade-FeraudDivision of Endocrinology and Metabolism (J.P.W.d.C., T.L.F., G.W.F., A.C.B.), Rush University Medical Center, Chicago Illinois 60612; Division of Endocrinology, Diabetes, and Metabolism (J.P.W.d.C., D.L.I., C.M.A.F., L.J.L., M.B.R.), University of Miami Miller School of Medicine, Miami, Florida 33101-6960; Biophysics Institute and School of Physical Education and Sports (J.P.W.d.C., D.L.I., M.B.R.), Federal University of Rio de Janeiro, 21941-901 Rio de Janeiro, Brazil; Developmental Disorders Program (M.O.R.), Center for Biological and Health Sciences, Mackenzie Presbyterian University, 01302 Sao Paulo, Brazil; Department of Endocrine Neurobiology (B.G.), Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, H-1083 Hungary; and Translational Medicine (G.W.F.), Federal University of Sao Paulo, 01302-907 Sao Paulo, Brazil.
Lattoya J LarteyDivision of Endocrinology and Metabolism (J.P.W.d.C., T.L.F., G.W.F., A.C.B.), Rush University Medical Center, Chicago Illinois 60612; Division of Endocrinology, Diabetes, and Metabolism (J.P.W.d.C., D.L.I., C.M.A.F., L.J.L., M.B.R.), University of Miami Miller School of Medicine, Miami, Florida 33101-6960; Biophysics Institute and School of Physical Education and Sports (J.P.W.d.C., D.L.I., M.B.R.), Federal University of Rio de Janeiro, 21941-901 Rio de Janeiro, Brazil; Developmental Disorders Program (M.O.R.), Center for Biological and Health Sciences, Mackenzie Presbyterian University, 01302 Sao Paulo, Brazil; Department of Endocrine Neurobiology (B.G.), Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, H-1083 Hungary; and Translational Medicine (G.W.F.), Federal University of Sao Paulo, 01302-907 Sao Paulo, Brazil.
Marcelo B RibeiroDivision of Endocrinology and Metabolism (J.P.W.d.C., T.L.F., G.W.F., A.C.B.), Rush University Medical Center, Chicago Illinois 60612; Division of Endocrinology, Diabetes, and Metabolism (J.P.W.d.C., D.L.I., C.M.A.F., L.J.L., M.B.R.), University of Miami Miller School of Medicine, Miami, Florida 33101-6960; Biophysics Institute and School of Physical Education and Sports (J.P.W.d.C., D.L.I., M.B.R.), Federal University of Rio de Janeiro, 21941-901 Rio de Janeiro, Brazil; Developmental Disorders Program (M.O.R.), Center for Biological and Health Sciences, Mackenzie Presbyterian University, 01302 Sao Paulo, Brazil; Department of Endocrine Neurobiology (B.G.), Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, H-1083 Hungary; and Translational Medicine (G.W.F.), Federal University of Sao Paulo, 01302-907 Sao Paulo, Brazil.
Miriam O RibeiroDivision of Endocrinology and Metabolism (J.P.W.d.C., T.L.F., G.W.F., A.C.B.), Rush University Medical Center, Chicago Illinois 60612; Division of Endocrinology, Diabetes, and Metabolism (J.P.W.d.C., D.L.I., C.M.A.F., L.J.L., M.B.R.), University of Miami Miller School of Medicine, Miami, Florida 33101-6960; Biophysics Institute and School of Physical Education and Sports (J.P.W.d.C., D.L.I., M.B.R.), Federal University of Rio de Janeiro, 21941-901 Rio de Janeiro, Brazil; Developmental Disorders Program (M.O.R.), Center for Biological and Health Sciences, Mackenzie Presbyterian University, 01302 Sao Paulo, Brazil; Department of Endocrine Neurobiology (B.G.), Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, H-1083 Hungary; and Translational Medicine (G.W.F.), Federal University of Sao Paulo, 01302-907 Sao Paulo, Brazil.
Balazs GerebenDivision of Endocrinology and Metabolism (J.P.W.d.C., T.L.F., G.W.F., A.C.B.), Rush University Medical Center, Chicago Illinois 60612; Division of Endocrinology, Diabetes, and Metabolism (J.P.W.d.C., D.L.I., C.M.A.F., L.J.L., M.B.R.), University of Miami Miller School of Medicine, Miami, Florida 33101-6960; Biophysics Institute and School of Physical Education and Sports (J.P.W.d.C., D.L.I., M.B.R.), Federal University of Rio de Janeiro, 21941-901 Rio de Janeiro, Brazil; Developmental Disorders Program (M.O.R.), Center for Biological and Health Sciences, Mackenzie Presbyterian University, 01302 Sao Paulo, Brazil; Department of Endocrine Neurobiology (B.G.), Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, H-1083 Hungary; and Translational Medicine (G.W.F.), Federal University of Sao Paulo, 01302-907 Sao Paulo, Brazil.
Antonio C BiancoDivision of Endocrinology and Metabolism (J.P.W.d.C., T.L.F., G.W.F., A.C.B.), Rush University Medical Center, Chicago Illinois 60612; Division of Endocrinology, Diabetes, and Metabolism (J.P.W.d.C., D.L.I., C.M.A.F., L.J.L., M.B.R.), University of Miami Miller School of Medicine, Miami, Florida 33101-6960; Biophysics Institute and School of Physical Education and Sports (J.P.W.d.C., D.L.I., M.B.R.), Federal University of Rio de Janeiro, 21941-901 Rio de Janeiro, Brazil; Developmental Disorders Program (M.O.R.), Center for Biological and Health Sciences, Mackenzie Presbyterian University, 01302 Sao Paulo, Brazil; Department of Endocrine Neurobiology (B.G.), Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, H-1083 Hungary; and Translational Medicine (G.W.F.), Federal University of Sao Paulo, 01302-907 Sao Paulo, Brazil.
University of Miami · USRush University Medical Center · USUniversidade Federal do Rio de Janeiro · BRHUN-REN Institute of Experimental Medicine · HUUniversidade Federal de São Paulo · BRUniversidade Presbiteriana Mackenzie · BR
Funding
Metabolic and Xenobiotic Control of Thyroid Hormone MetabolismR01DK077148 · NIDDK · UNIVERSITY OF TEXAS MED BR GALVESTON · PI ANTONIO C BIANCO · 2007 to 2026
$4.5MNIDDK NIH HHS R01 DK077148PHS HHS NIDDK R0165055
Abstract
The type 2 deiodinase (D2) activates the prohormone T4 to T3. D2 is expressed in skeletal muscle (SKM), and its global inactivation (GLOB-D2KO mice) reportedly leads to skeletal muscle hypothyroidism and impaired differentiation. Here floxed Dio2 mice were crossed with mice expressing Cre-recombinase under the myosin light chain 1f (cre-MLC) to disrupt D2 expression in the late developmental stages of skeletal myocytes (SKM-D2KO). This led to a loss of approximately 50% in D2 activity in neonatal and adult SKM-D2KO skeletal muscle and about 75% in isolated SKM-D2KO myocytes. To test the impact of Dio2 disruption, we measured soleus T3 content and found it to be normal. We also looked at the expression of T3-responsive genes in skeletal muscle, ie, myosin heavy chain I, α-actin, myosin light chain, tropomyosin, and serca 1 and 2, which was preserved in neonatal SKM-D2KO hindlimb muscles, at a time that coincides with a peak of D2 activity in control animals. In adult soleus the baseline level of D2 activity was about 6-fold lower, and in the SKM-D2KO soleus, the expression of only one of five T3-responsive genes was reduced. Despite this, adult SKM-D2KO animals performed indistinguishably from controls on a treadmill test, running for approximately 16 minutes and reached a speed of about 23 m/min; muscle strength was about 0.3 mN/m·g body weight in SKM-D2KO and control ankle muscles. In conclusion, there are multiple sources of D2 in the mouse SKM, and its role is limited in postnatal skeletal muscle fibers.
Indexed as
Signal TransductionAdipose Tissue, BrownAnimalsAnimals, NewbornCells, CulturedGene ExpressionIodide PeroxidaseIodothyronine Deiodinase Type IIMaleMice, KnockoutMice, TransgenicMuscle Fibers, SkeletalMuscle, SkeletalMuscle StrengthMyosin Heavy ChainsPhysical Conditioning, AnimalIodide PeroxidaseIodothyronine Deiodinase Type IImyosin heavy chain-1, mouseMyosin Heavy ChainsSarcoplasmic Reticulum Calcium-Transporting ATPasesThyroid HormonesThyroxineTriiodothyronineTropomyosin
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.