ArticlePathogens (Basel, Switzerland)2015
Neutrophils Do Not Express IL-17A in the Context of Acute Oropharyngeal Candidiasis.
Article in Pathogens (Basel, Switzerland), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 26 citations in OpenAlex.
- Molecular mechanisms of neutrophil regulatory network in anti-Candida infection.Frontiers in immunology · 2025Review
- Of Mycelium and Men: Inherent Human Susceptibility to Fungal Diseases.Pathogens (Basel, Switzerland) · 2023Review
- Decoding the host-pathogen interspecies molecular crosstalk during oral candidiasis in humans: anFrontiers in genetics · 2023Article
- ITK independent development of Th17 responses during hypersensitivity pneumonitis driven lung inflammation.Communications biology · 2022Article
- Immune Sensing ofJournal of fungi (Basel, Switzerland) · 2021Review
- Oral epithelial IL-22/STAT3 signaling licenses IL-17-mediated immunity to oral mucosal candidiasis.Science immunology · 2020Article
- In vitro immune responses of human PBMCs against Candida albicans reveals fungal and leucocyte phenotypes associated with fungal persistence.Scientific reports · 2020Article
- Review
- Immunopathology of Recurrent Vulvovaginal Infections: New Aspects and Research Directions.Frontiers in immunology · 2019Review
- Extracellular ATP and IL-23 Form a Local Inflammatory Circuit Leading to the Development of a Neutrophil-Dependent Psoriasiform Dermatitis.The Journal of investigative dermatology · 2018Article
- Mucocutaneous IL-17 immunity in mice and humans: host defense vs. excessive inflammation.Mucosal immunology · 2018Review
- A Reappraisal on the Potential Ability of Human Neutrophils to Express and Produce IL-17 Family MembersFrontiers in immunology · 2018Article
- Candida albicans-epithelial interactions and induction of mucosal innate immunity.Current opinion in microbiology · 2017Review
- Cytokines IL-17 and IL-22 in the host response to infection.Pathogens and disease · 2016Review
- IL-17 Receptor Signaling in Oral Epithelial Cells Is Critical for Protection against Oropharyngeal Candidiasis.Cell host & microbe · 2016Article
- Antibody blockade of IL-17 family cytokines in immunity to acute murine oral mucosal candidiasis.Journal of leukocyte biology · 2016Article
- mTOR Mediates IL-23 Induction of Neutrophil IL-17 and IL-22 Production.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Interleukin 17-Mediated Host Defense against Candida albicans.Pathogens (Basel, Switzerland) · 2015Review
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
IL-17 protects against pathogens by acting on nonhematopoietic cells to induce neutrophil recruitment through upregulation of chemokines and G-CSF. IL-17- and Th17-deficient humans and mice are susceptible to mucosal Candida albicans infections, linked to impaired neutrophil responses. IL-17 production is traditionally associated with CD4+ Th17 cells. However, IL-17 is also expressed during innate responses to facilitate rapid pathogen clearance. Innate IL-17-expressing cells include various lymphocyte-type subsets, including ILC3, NKT, γδ-T and "natural" Th17 (nTh17) cells. Some reports suggest that neutrophils can express IL-17 during fungal infections. Here, we asked whether neutrophils serve as a source of IL-17 during acute oropharyngeal candidiasis (OPC) using an IL-17A fate-tracking reporter mouse. Mice were subjected to OPC for two days, and oral tissue was analyzed by flow cytometry. IL-17A was expressed by γδ-T cells and TCRβ+ natural Th17 (nTh17) cells, as recently reported. Although infiltrating neutrophils were recruited to the tongue following infection, they did not express the IL-17A reporter. Moreover, neutrophil-depleted mice exhibited normal transcription of both Il17a and downstream IL-17-dependent gene targets after Candida challenge. Thus, in acute OPC, neutrophils are not a measurable source of IL-17 production, nor are they necessary to trigger IL-17-dependent gene expression, although they are essential for ultimate pathogen control.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.