ArticleNutrients2015
Higher Body Iron Is Associated with Greater Depression Symptoms among Young Adult Men but not Women: Observational Data from the Daily Life Study.
Article in Nutrients, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 28 citations in OpenAlex.
- The Relationship Between Trace Elements and Depression.Nutrients · 2026Review
- Associations of cerebrospinal fluid metal ion profiles with depressive symptoms in active smokers: a cross-sectional network analysis.Frontiers in psychiatry · 2026Article
- Current Strategies and Future Directions of Wearable Biosensors for Measuring Stress Biochemical Markers for Neuropsychiatric Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Whole-exome sequencing identifies protein-coding variants associated with brain iron in 29,828 individuals.Nature communications · 2024Article
- Iron status in Swiss adolescents with paediatric major depressive disorder and healthy controls: a matched case-control study.European journal of nutrition · 2024Article
- Nrf2 regulates iron-dependent hippocampal synapses and functional connectivity damage in depression.Journal of neuroinflammation · 2023Article
- Review
- Alterations in brain iron deposition with progression of late-life depression measured by magnetic resonance imaging (MRI)-based quantitative susceptibility mapping.Quantitative imaging in medicine and surgery · 2022Article
- Iron status and mental disorders: A Mendelian randomization study.Frontiers in nutrition · 2022Article
- Nutritional therapy can reduce the burden of depression management in low income countries: A review.IBRO neuroscience reports · 2021Review
- Assessing the Evidence of Micronutrients on Depression among Children and Adolescents: An Evidence Gap Map.Advances in nutrition (Bethesda, Md.) · 2020Article
- Major Depression in Children with Transfusion-Dependent Thalassemia Is Strongly Associated with the Combined Effects of Blood Transfusion Rate, Iron Overload, and Increased Pro-inflammatory Cytokines.Neurotoxicity research · 2020Article
- Quantitative Susceptibility Mapping Reveals an Association between Brain Iron Load and Depression Severity.Frontiers in human neuroscience · 2017Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Studies investigating possible associations between iron status and mood or depressive symptoms have reported inconsistent results. However, they have neither used body iron to measure iron status nor measured mood using daily measures. We investigated whether body iron was associated with depressive symptoms, daily mood, daily tiredness, difficulty concentrating, and stress in young adult women and men. Young adult (17-25 years) women (n = 562) and men (n = 323) completed the Center for Epidemiologic Studies Depression Scale, then reported negative and positive mood, and other states daily for 13 days. Non-fasting venous blood was collected to determine hemoglobin, serum ferritin and soluble transferrin receptor (to calculate body iron), C-reactive protein, and alpha-1-acid glycoprotein concentration. Regression models tested linear associations between body iron and the outcome variables, controlling for possible confounders. No associations were found between body iron and the outcome variables in women. However, higher body iron was associated with more depressive symptoms in men (3.4% more per body iron mg/kg; 95% confidence intervals (CI): 0.8%, 5.9%). In young adult women, body iron is unlikely to be associated with significant deficits in mood or depressive symptoms. However, higher body iron may be associated with more depressive symptoms in young adult men.
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