ArticleMolecules (Basel, Switzerland)2015
Antibacterial Activity of Protocatechuic Acid Ethyl Ester on Staphylococcus aureus Clinical Strains Alone and in Combination with Antistaphylococcal Drugs.
Article in Molecules (Basel, Switzerland), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 31 citations in OpenAlex.
- Silver-Bacterial Cellulose-Molecules (Basel, Switzerland) · 2026Article
- Synergistic activity of mupirocin in combination with protocatechuic acid ethyl ester against mupirocin-resistant MRSA.Frontiers in cellular and infection microbiology · 2026Article
- Bioactive Phenolic Compounds from Rambutan (International journal of molecular sciences · 2025Article
- Comparative Analysis of Polyphenolic Acids from VariousFoods (Basel, Switzerland) · 2025Article
- Antibacterial phenolic compounds from the flowering plants of Asia and the Pacific: coming to the light.Pharmaceutical biology · 2024Review
- Synergistic Interactions between Selected β-Lactam Antibiotics and Cinnamic Acid and Its Chosen Derivatives.Antibiotics (Basel, Switzerland) · 2024Article
- Screening Tests for the Interaction ofAntibiotics (Basel, Switzerland) · 2024Article
- Article
- Comprehensive overview of different medicinal parts fromFrontiers in pharmacology · 2024Review
- The Array of Antibacterial Action of Protocatechuic Acid Ethyl Ester and Erythromycin on Staphylococcal Strains.Antibiotics (Basel, Switzerland) · 2022Article
- Protocatechuic acid: A novel detoxication agent of fumonisin B1 for poultry industry.Frontiers in veterinary science · 2022Article
- Phytochemical Profile and Microbiological Activity of Some Plants Belonging to the Fabaceae Family.Antibiotics (Basel, Switzerland) · 2021Article
- Enhanced Activity and Sustained Release of Protocatechuic Acid, a Natural Antibacterial Agent, from Hybrid Nanoformulations with Zinc Oxide Nanoparticles.International journal of molecular sciences · 2021Article
- In vivo Antibacterial Activity of Star Anise (Infection and drug resistance · 2021Article
- Phytochemical Profile and Biological Activities of Tendrils and Leaves Extracts from a Variety ofAntioxidants (Basel, Switzerland) · 2020Article
- Phenolic Compounds Diminish Antibiotic Resistance ofInternational journal of environmental research and public health · 2018Review
- Antimicrobial Potential of Caffeic Acid againstBioMed research international · 2018Article
- Catechin Hydrate Augments the Antibacterial Action of Selected Antibiotics against Staphylococcus aureus Clinical Strains.Molecules (Basel, Switzerland) · 2016Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of the presented study was to examine in vitro the antibacterial activity of protocatechuic acid ethyl ester (ethyl 3,4-dihydroxybenzoate, EDHB) against Staphylococcus aureus clinical isolates alone and in the combination with four selected antibiotics. The EDHB antimicrobial activity was tested against twenty S. aureus strains isolated from the clinical samples, and three reference strains. The phenotypes and genotypes of resistance to methicillin for the tested strains were defined as well as the phenotypic resistance to macrolides, lincosamides and streptogramin B (MLSB). EDHB displayed diverse activity against examined S. aureus strains with the minimal inhibitory concentration (MIC) within the range from 64 to 1024 µg/mL. Addition of ¼ MIC of EDHB into the Mueller-Hinton Agar (MHA) resulted in augmented antibacterial effect in the presence of clindamycin. In the case of cefoxitin no synergistic effect with EDHB was noted. For erythromycin and vancomycin the decrease of mean MICs in the presence of EDHB was observed but did not reach statistical significance. The results of the present study showed that in vitro EDHB possesses antibacterial activity against S. aureus clinical strains and triggers a synergistic antimicrobial effect with clindamycin and to the lesser extent with erythromycin and vancomycin.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.