ArticleOncotarget2015
NOP14 suppresses breast cancer progression by inhibiting NRIP1/Wnt/β-catenin pathway.
Article in Oncotarget, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 31 citations in OpenAlex.
- Investigation of potential prognostic biomarkers for colorectal cancer.Archives of medical science : AMS · 2025Article
- Roles and action mechanisms of NRIP1 in pre-eclampsia.Genes & genomics · 2024Article
- The transcriptional regulatory network modulating human trophoblast stem cells to extravillous trophoblast differentiation.Nature communications · 2024Article
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- Increased expression of NOP14 is associated with improved prognosis due to immune regulation in colorectal cancer.BMC gastroenterology · 2022Article
- A New RBPs-Related Signature Predicts the Prognosis of Colon Adenocarcinoma Patients.Frontiers in oncology · 2021Article
- Integrated analysis of RNA-binding proteins in human colorectal cancer.World journal of surgical oncology · 2020Article
- Regulation of LCoR and RIP140 expression in cervical intraepithelial neoplasia and correlation with CIN progression and dedifferentiation.Journal of cancer research and clinical oncology · 2020Article
- EMG1 interacts with NOP14 to regulate the growth, migration, and invasion of melanoma cells via the Wnt/β-catenin pathway.Translational cancer research · 2020Article
- CCND1, NOP14 and DNMT3B are involved in miR-502-5p-mediated inhibition of cell migration and proliferation in bladder cancer.Cell proliferation · 2020Article
- Prognostic relevance of RIP140 and ERβ expression in unifocal versus multifocal breast cancers: a preliminary report.International journal of molecular sciences · 2019Article
- [miR-122-5p inhibits the proliferation of melanoma cells by targeting NOP14].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2018Article
- NOP14 inhibits melanoma proliferation and metastasis by regulating Wnt/β-catenin signaling pathway.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas · 2018Article
- Importance of RIP140 and LCoR Sub-Cellular Localization for Their Association With Breast Cancer Aggressiveness and Patient Survival.Translational oncology · 2018Article
- Synergistic effect of receptor-interacting protein 140 and simvastatin on the inhibition of proliferation and survival of hepatocellular carcinoma cells.Oncology letters · 2018Article
- A cautionary tale of sense-antisense gene pairs: independent regulation despite inverse correlation of expression.Nucleic acids research · 2017Article
- Complex regulation of LCoR signaling in breast cancer cells.Oncogene · 2017Article
- Polymorphisms and expression pattern of circular RNA circ-ITCH contributes to the carcinogenesis of hepatocellular carcinoma.Oncotarget · 2017Article
- The Expression of NRIP1 and LCOR in Endometrioid Endometrial Cancer.In vivo (Athens, Greece)Article
Corrections and comments
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Authors and funding
17 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
NOP14, which is functionally conserved among eukaryotes, has been implicated in cancer development. Here, we show that NOP14 is poorly expressed in breast cancer cells and invasive breast cancer tissues. In vivo and in vitro studies indicated that NOP14 suppressed the tumorigenesis and metastasis of breast cancer cells. Further investigations revealed that NOP14 enhanced ERα expression and inhibited the Wnt/β-catenin pathway by up-regulating NRIP1 expression. Survival analysis indicated that low NOP14 expression was significantly associated with poor overall survival (P = 0.0006) and disease-free survival (P = 0.0007), suggesting that NOP14 is a potential prognostic factor in breast cancer. Taken together, our findings reveal that NOP14 may suppress breast cancer progression and provide new insights into the development of targeted therapeutic agents for breast cancer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.