Evidence map›Paper›PMID 26213453›Full record

ArticleInformation processing in medical imaging : proceedings of the ... conference2015

Functional Nonlinear Mixed Effects Models for Longitudinal Image Data.

Xinchao Luo, Lixing Zhu, Linglong Kong, Hongtu Zhu

Abstract read
In one paragraph

Article in Information processing in medical imaging : proceedings of the ... conference, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 71% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 4 countries.

Xinchao Luo
Lixing Zhu
Linglong Kong
Hongtu Zhu
Imaging Center · USHong Kong Baptist University · HKUniversity of Alberta · CA

Funding

UNC CLINICAL AND TRANSLATIONAL SCIENCE AWARD: BPCAUL1RR025747 · NCRR · UNIV OF NORTH CAROLINA CHAPEL HILL · PI RUNGE, MARSCHALL S. · 2008 to 2011
$44.6M
North Carolina Translational & Clinical Sciences Institute (NC TraCS)UL1TR001111 · NCATS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BUSE, JOHN BERNARD, CAREY, TIMOTHY S · 2013 to 2017
$43.9M
Statistical Analysis of Biomedical Imaging Data in Curved SpaceR01MH086633 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI IBRAHIM, JOSEPH G · 2010 to 2018
$2.9M
Genome-wide Identification of Variants Affecting Early Human Brain DevelopmentR01MH092335 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KNICKMEYER, REBECCA · 2011 to 2015
$2.5M
SCH: Proactive Health Monitoring Using Individualized Analysis of Tissue ElasticityR01EB020426 · NIBIB · UNIV OF NORTH CAROLINA CHAPEL HILL · PI CHEN, RONALD, JOJIC, VLADIMIR · 2014 to 2016
$653k
NCATS NIH HHS UL1 TR001111NCRR NIH HHS RR025747NIBIB NIH HHS R01 EB020426NIMH NIH HHS MH086633NIMH NIH HHS MH092335NIMH NIH HHS R01 MH086633
6 · The paper itself

Abstract

Motivated by studying large-scale longitudinal image data, we propose a novel functional nonlinear mixed effects modeling (FNMEM) framework to model the nonlinear spatial-temporal growth patterns of brain structure and function and their association with covariates of interest (e.g., time or diagnostic status). Our FNMEM explicitly quantifies a random nonlinear association map of individual trajectories. We develop an efficient estimation method to estimate the nonlinear growth function and the covariance operator of the spatial-temporal process. We propose a global test and a simultaneous confidence band for some specific growth patterns. We conduct Monte Carlo simulation to examine the finite-sample performance of the proposed procedures. We apply FNMEM to investigate the spatial-temporal dynamics of white-matter fiber skeletons in a national database for autism research. Our FNMEM may provide a valuable tool for charting the developmental trajectories of various neuropsychiatric and neurodegenerative disorders.

Indexed as

Models, StatisticalSubtraction TechniqueAdolescentAgingAutistic DisorderBrainChildChild, PreschoolComputer SimulationData Interpretation, StatisticalFemaleHumansImage EnhancementImage Interpretation, Computer-AssistedInfantInfant, Newborn

Identifiers

PMID26213453
PMCPMC4511397
OpenAlexW2399294503

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.