Evidence map›Paper›PMID 26213433›Full record

ArticleNuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment2014

Comparison of first pass bolus AIFs extracted from sequential

Eleanor Evans, Stephen J Sawiak, Alexander O Ward, Guido Buonincontri, Robert C Hawkes, T Adrian Carpenter

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.5field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Eleanor EvansWolfson Brain Imaging Centre, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK.
Stephen J SawiakWolfson Brain Imaging Centre, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK ; Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK.
Alexander O WardWolfson Brain Imaging Centre, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK.
Guido BuonincontriWolfson Brain Imaging Centre, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK.
Robert C HawkesWolfson Brain Imaging Centre, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK.
T Adrian CarpenterWolfson Brain Imaging Centre, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK.
Addenbrooke's Hospital · GBUniversity of Cambridge · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Accurate kinetic modelling of in vivo physiological function using positron emission tomography (PET) requires determination of the tracer time-activity curve in plasma, known as the arterial input function (AIF). The AIF is usually determined by invasive blood sampling methods, which are prohibitive in murine studies due to low total blood volumes. Extracting AIFs from PET images is also challenging due to large partial volume effects (PVE). We hypothesise that in combined PET with magnetic resonance imaging (PET/MR), a co-injected bolus of MR contrast agent and PET ligand can be tracked using fast MR acquisitions. This protocol would allow extraction of a MR AIF from MR contrast agent concentration-time curves, at higher spatial and temporal resolution than an image-derived PET AIF. A conversion factor could then be applied to the MR AIF for use in PET kinetic analysis. This work has compared AIFs obtained from sequential DSC-MRI and PET with separate injections of gadolinium contrast agent and

Identifiers

PMID26213433
PMCPMC4510925
OpenAlexW1971341492

What OpenQuestion holds

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LicenceTDM
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.