Evidence map›Paper›PMID 26213352›Full record

ArticleJournal of psychosomatic research2015

Do personality traits moderate the manifestation of type 2 diabetes genetic risk?

Iva Čukić, René Mõttus, Michelle Luciano, John M Starr, Alexander Weiss, Ian J Deary

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of psychosomatic research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. A Qualitative Study Exploring the Mechanisms Underlying Self-Management Behaviours Among Community-Dwelling Type 2 Diabetes Mellitus Patients in Nanjing, China.Health expectations : an international journal of public participation in health care and health policy · 2025
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  5. [Relationship between the five-factor model of personality traits and self-management attitude of patients with type 2 diabetes].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Iva ČukićCentre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, UK; Department of Psychology, University of Edinburgh, UK. Electronic address: icukic@exseed.ed.ac.uk.
René MõttusCentre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, UK; Department of Psychology, University of Edinburgh, UK; Department of Psychology, University of Tartu, Estonia. Electronic address: rene.mottus@ed.ac.uk.
Michelle LucianoCentre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, UK; Department of Psychology, University of Edinburgh, UK. Electronic address: michelle.luciano@ed.ac.uk.
John M StarrCentre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, UK; Geriatric Medicine Unit, Western General Hospital, Edinburgh, UK. Electronic address: jstarr@staffmail.ed.ac.uk.
Alexander WeissDepartment of Psychology, University of Edinburgh, UK. Electronic address: alex.weiss@ed.ac.uk.
Ian J DearyCentre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, UK; Department of Psychology, University of Edinburgh, UK. Electronic address: i.deary@ed.ac.uk.

Funding

Biotechnology and Biological Sciences Research Council BB/F019394/1Medical Research Council G0700704Medical Research Council MR/K026992/1
6 · The paper itself

Abstract

objectiveTo test whether personality traits moderate type 2 diabetes (T2D) genetic risk.

methodsUsing a large community-dwelling sample (n=837, Mage=69.59±0.85years, 49% males) we fitted a series of linear regression models predicting glycated haemoglobin (HbA1c) from T2D polygenic risk - aggregation of small individual effects of a large number of single nucleotide polymorphisms (SNPs) - and five personality traits. We tested the main effects of personality traits and their interactions with T2D polygenic risk score, controlling for age and sex. The models in the final set were adjusted for cognitive ability, highest educational qualification, and occupational class.

resultsLower levels of openness were associated with heightened levels of HbA1c (β=-0.014, p=.032). There was a significant interaction between T2D polygenic risk score and agreeableness: lower agreeableness was related to a stronger association between T2D polygenic risk and HbA1c (β=-0.08, p=.021). In the model adjusted for cognitive ability, the main effect of openness was not significant (β=-0.08, p=.057). The interaction between agreeableness and T2D polygenic risk was still present after controlling for cognitive ability and socioeconomic status indicators, and the interaction between conscientiousness and polygenic risk score was also significant: lower conscientiousness was associated with a stronger association between T2D polygenic risk and HbA1c levels (β=0.09, p=.04).

conclusionsPersonality may be associated with markers of diabetes, and may moderate the expression of its genetic risk.

Indexed as

AgedCohort StudiesDiabetes Mellitus, Type 2FemaleHumansMalePersonalityRisk FactorsAgreeablenessCognitive abilityConscientiousnessGene–trait interactionHbA1cOpennessPersonalityPolygenic riskType 2 diabetes

Identifiers

PMID26213352
PMCPMC4579920

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.