Evidence map›Paper›PMID 26213343›Full record

ArticleSchizophrenia research2015

Premorbid multivariate prediction of adult psychosis-spectrum disorder: A high-risk prospective investigation.

Jason Schiffman, Emily Kline, Nicole D Jameson, Holger J Sorensen, Shana Dodge, Thomas Tsuji, Erik L Mortensen, Sarnoff A Mednick

Open access · greenAbstract read
In one paragraph

Article in Schizophrenia research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 93% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Jason SchiffmanDepartment of Psychology, University of Maryland, Baltimore County, United States. Electronic address: schiffma@umbc.edu.
Emily KlineDepartment of Psychiatry, Harvard Medical School, Beth Israel Deaconess Medical Center, United States.
Nicole D JamesonDepartment of Psychology, University of Maryland, Baltimore County, United States.
Holger J SorensenDepartment of Psychiatry, Amager Hospital, Copenhagen University Hospital, Capital Region of Denmark, Denmark; Institute of Public Health, Center for Healthy Aging, University of Copenhagen, Denmark.
Shana DodgeUniversity of Hawaii, United States.
Thomas TsujiDepartment of Psychology, University of Maryland, Baltimore County, United States.
Erik L MortensenInstitute of Public Health, Center for Healthy Aging, University of Copenhagen, Denmark; Institute of Preventive Medicine, Copenhagen University Hospital, Denmark.
Sarnoff A MednickInstitute of Preventive Medicine, Copenhagen University Hospital, Denmark; University of Southern California, United States.
University of Maryland, Baltimore County · USCopenhagen University Hospital · DKBeth Israel Deaconess Medical Center · USUniversity of Copenhagen · DKUniversity of Hawaii System · US

Funding

Neurologic Predictors of SchizophreniaR03MH076846 · NIMH · UNIVERSITY OF MARYLAND BALTIMORE COUNTY · PI SCHIFFMAN, JASON E · 2007 to 2008
$138k
NIMH NIH HHS R03 MH076846NIMH NIH HHS R03MH076846
6 · The paper itself

Abstract

Premorbid prediction of psychosis-spectrum disorders has implications for both understanding etiology and clinical identification. The current study used a longitudinal high-risk for psychosis design that included children of parents with schizophrenia as well as two groups of controls (children whose parents had no mental illness, and children with at least one parent with a non-psychotic psychiatric diagnosis). Premorbid neurological factors and an indication of social function, as measured when participants were 10-13years of age, were combined to predict psychosis-spectrum disorders in adulthood. Through a combination of childhood predictors, the model correctly classified 82% (27 of 33) of the participants who eventually developed a psychosis-spectrum outcome in adulthood. With replication, multivariate premorbid prediction, including genetic risk, social, and neurological variables, could potentially be a useful complementary approach to identifying individuals at risk for developing psychosis-spectrum disorders.

Indexed as

Schizophrenic PsychologyAdultAnalysis of VarianceFemaleHumansLongitudinal StudiesMaleNeurologic ExaminationPredictive Value of TestsPsychiatric Status Rating ScalesPsychotic DisordersRetrospective StudiesRisk AssessmentROC CurveSchizophreniaHigh-riskNeurologicalPredictionPremorbidPsychosisSocial

Identifiers

PMID26213343
PMCPMC4591206
OpenAlexW2096855455

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.