ArticleBJOG : an international journal of obstetrics and gynaecology2015
Progression from severe sepsis in pregnancy to death: a UK population-based case-control analysis.
Article in BJOG : an international journal of obstetrics and gynaecology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- Rapid systematic review on risks and outcomes of sepsis: the influence of risk factors associated with health inequalities.International journal for equity in health · 2024Pooled it
- Severe Maternal Morbidity Among Adolescents Aged 10-19 in California, 2001-2020.The Journal of adolescent health : official publication of the Society for Adolescent Medicine · 2026Article
- Use of evidence from the UK Obstetric Surveillance System in policy and clinical practice: a descriptive study using citation tracking.NIHR open research · 2026Article
- Reducing post-cesarean sepsis: Current best practice in prevention and treatment.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2025Article
- Risk factors for maternal pyrexia, infection and sepsis in four hospitals providing maternity care in New South Wales, Australia: a cohort study.Frontiers in global women's health · 2025Article
- Aetiology and use of antibiotics in pregnancy-related infections: results of the WHO Global Maternal Sepsis Study (GLOSS), 1-week inception cohort.Annals of clinical microbiology and antimicrobials · 2024Article
- Maternal Sepsis in Italy: A Prospective, Population-Based Cohort and Nested Case-Control Study.Microorganisms · 2022Article
- How should we interpret lactate in labour? A reference study.BJOG : an international journal of obstetrics and gynaecology · 2022Article
- Incidence, morbidity, and associated factors for sepsis in women hospitalized for delivery: a nationwide retrospective observational population-based study in Canada.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2022Observational
- Evaluation of the etiology and risk factors for maternal sepsis: A single center study in Guangzhou, China.World journal of clinical cases · 2021Article
- Comparison of Sequential Organ Failure Assessment (SOFA) and Sepsis in Obstetrics Score (SOS) in Women with Pregnancy-Associated Sepsis with Respect to Critical Care Admission and Mortality: A Prospective Observational Study.Journal of obstetrics and gynaecology of India · 2021Article
- Applicability of the WHO maternal near-miss tool: A nationwide surveillance study in Suriname.Journal of global health · 2020Article
- The Impact of Evidence-Based Transformation on Healthcare Practices at a Teaching Hospital.Cureus · 2020Article
- An Observational Cohort Study Evaluating Antimicrobial Use in Peripartum Sepsis: A Tendency towards Overdiagnosis?Pharmacy (Basel, Switzerland) · 2020Article
- The Co-development and Feasibility-Testing of an Innovative Digital Animation Intervention (DAISI) to Reduce the Risk of Maternal Sepsis in the Postnatal Period.Maternal and child health journal · 2020Article
- The golden hour of sepsis: An in-depth analysis of sepsis-related maternal mortality in middle-income country Suriname.PloS one · 2018Article
- Progression from severe sepsis in pregnancy to death: a UK population-based case-control analysis.BJOG : an international journal of obstetrics and gynaecology · 2015Article
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Authors and funding
5 authors at 1 institution in 1 country.
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Abstract
objectiveTo identify factors associated with progression from pregnancy-associated severe sepsis to death in the UK.
designA population-based case-control analysis using data from the UK Obstetric Surveillance System (UKOSS) and the UK Confidential Enquiry into Maternal Death (CEMD).
settingAll pregnancy care and death settings in UK hospitals. POPULATION: All non-influenza sepsis-related maternal deaths (January 2009 to December 2012) were included as cases (n = 43), and all women who survived severe non-influenza sepsis in pregnancy (June 2011 to May 2012) were included as controls (n = 358).
methodsCases and controls were identified using the CEMD and UKOSS. Multivariable logistic regression was used to estimate adjusted odds ratios (aOR) with 95% confidence intervals.
main outcome measuresOdds ratios for socio-demographic, medical, obstetric and management factors in women who died from sepsis, compared with those who survived.
resultsFour factors were included in the final regression model. Women who died were more likely to have never received antibiotics [aOR = 22.7, 95% confidence interval (CI) 3.64-141.6], to have medical comorbidities (aOR = 2.53, 95%CI 1.23-5.23) and to be multiparous (aOR = 3.57, 95%CI 1.62-7.89). Anaemia (aOR = 13.5, 95%CI 3.17-57.6) and immunosuppression (aOR = 15.0, 95%CI 1.93-116.9) were the two most important factors driving the association between medical comorbidities and progression to death.
conclusionsThere must be continued vigilance for the risks of infection in pregnant women with medical comorbidities. Improved adherence to national guidelines, alongside prompt recognition and treatment with antibiotics, may reduce the burden from sepsis-related maternal deaths. TWEETABLE ABSTRACT: Medical comorbidities, multiparity and antibiotic delays increase the risk of death from maternal sepsis.
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